Cancer Stem Cell News 9.09 March 11, 2020 | |
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TOP STORYHormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis Chemical carcinogenesis of the stomach was associated with loss of gastrin-expressing endocrine cells, increased symmetric stem cell division, glandular fission, and more rapid stem cell lineage tracing. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists proposed a new therapeutic strategy: investigating the “transitional” cells that represented the stage between normal lung stem cells and lung CSCs. [Oncogene] Full Article Investigators report that miR-6778-5p, a noncanonical miRNA, acted as a crucial regulator for maintenance of cancer stem cell stemness in Drosha-silenced gastric cancer cells. [Cancer Lett] Full Article Pyridoxine Enhances Chemo-Responsiveness of Breast Cancer Stem Cells via Redox Reconditioning Scientists observed that breast CSCs were resistant to DNA damage and generated low ROS upon doxorubicin treatment. [Free Radic Biol Med] Abstract | Graphical Abstract Knockdown of sex-determining region Y-box2 (SOX2) ceased stemness properties, angiogenesis, and vasculogenic mimicry, along with decreased expression of CD133, CD31, and VE-cadherin as observed in functional experiments. [Cell Death Dis] Full Article The expression of LINC00324 in hepatocellular carcinoma tissues and liver cancer stem cell lines was examined using RT-qPCR. The interaction among LINC00324, PU box binding protein and FasL was identified with RIP, ChIP and dual-luciferase reporter gene assays. [FASEB J] Full Article Researchers explored cell-to-cell Wnt and stemness heterogeneity in hepatocellular carcinoma by labeling freshly isolated cancer cells with a Wnt-specific reporter. [Stem Cell Reports] Full Article The lactate dependent effects on stemness properties were abrogated by the MCT1/lactate-uptake inhibitor 7ACC2 or MCT1 knock-down. [Cancers] Abstract | Full Article Download Treatment with KYA1797K, a small molecule that destabilized both β-catenin and RAS via Axin binding, effectively suppressed the stemness of CSCs as was shown in colorectal cancer spheroids and small intestinal tumors. [Cell Commun Signal] Full Article Flow sorted breast CSCs and non-breast CSCs were tested for their characteristic of stemness by mammosphere formation assay. [Cell Commun Signal] Full Article A culture system was setup to enrich CSCs from bladder cancer, lung cancer, colorectal cancer, and osteosarcoma cell lines, through sphere formation. [IUBMB Life] Abstract Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSA Perspective on Challenges and Opportunities in Characterizing Oral Cancer Stem Cells The authors discuss different markers, CD44, ALDH1, CD271 and others that have used for identifying and isolating CSCs from primary head and neck, and oral squamous cell carcinomas. [Front Biosci] Full Article Alterations of Cell Cycle Genes in Cancer: Unmasking the Role of Cancer Stem Cells Scientists describe epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs. [Mol Biol Rep] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSCCNY-MSKCC Cancer Research Partnership Receives $14M NIH Grant The grant will fund a new research education program for City College students and ongoing cancer outreach in the Harlem community. [The City College of New York] Press Release CPRIT Awards Research Grant to Texas Tech HSC’s Reynolds The Cancer Prevention and Research Institute of Texas (CPRIT) in February announced a $1,196,214 grant to C. Patrick Reynolds, M.D., Ph.D., director for the School of Medicine Cancer Center at the Texas Tech University Health Sciences Center (TTUHSC). [Texas Tech University Health Sciences Center] Press Release | |
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POLICY NEWSNew Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial Nearly two years ago, Charles River Laboratories paid $800 million for a company called MPI Research to bolster its business running clinical trials for drug makers and other companies. But Charles River did not know one MPI employee was an also undercover agent for the Humane Society of the United States and secretly filmed experiments conducted on various dogs, which were later publicized on the internet. [STAT News] Editorial
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EVENTSNEW Diverse Organisms and Common Mechanisms in Cell-Cell Fusion Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Leukemia Stem Cell Research (Dana Farber Cancer Institute) Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine) Research Fellow – Leukemia Stem Cell Biology (University College London) Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester) Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg) Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University) Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University) Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University) Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg) Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute) Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation) Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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