Cancer Stem Cell News Volume 9.16 | Apr 29 2020

TOP STORY

YAP1 Mediates Gastric Adenocarcinoma Peritoneal Metastases That Are Attenuated by YAP1 Inhibition

Yes-associated protein 1 was highly upregulated in peritoneal carcinomatosis tumor cells, conferred CSC properties and appeared to be a metastatic driver. [Gut] Abstract

(Ranked by impact factor of the journal)

LGR5 Marks Targetable Tumor-Initiating Cells in Mouse Liver Cancer

Scientists report the enrichment of LGR5 expressing cells, a well-recognized stem cell marker in mouse liver tumors, and the upregulation of LGR5 expression in human hepatocellular carcinoma. [Nat Commun] Full Article

HyperTRIBE Uncovers Increased MUSASHI-2 RNA Binding Activity and Differential Regulation in Leukemic Stem Cells

The authors discovered a significant increase in RNA binding activity of MUSASHI-2 9 (MSI2) in leukemic stem cells compared with normal hematopoietic stem and progenitor cells, resulting in selective regulation of MSI2’s oncogenic targets. [Nat Commun] Full Article

ERK1/2-Nanog Signaling Pathway Enhances CD44⁺ Cancer Stem-Like Cell Phenotypes and Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinomas

Nanog levels were significantly higher in CD44⁺ head and neck squamous cell carcinomas spheroids than in CD44^– spheroids, and further increased when grown as spheroids to enrich for CSCs. [Cell Death Dis] Full Article

Glioma Stem Cell (GSC)-derived Autoschizis-Like Products Confer GSC Niche Properties Involving M1-like Tumor-Associated Macrophages

Autoschizis-like products (ALPs) were found to be specifically engulfed by macrophages expressing a tumor-associated macrophage (TAM) marker CD204. ALPs from glioma stem cells (GSCs) had higher activity for the TAM development than those from non-GSCs. [Stem Cells] Abstract

β-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells

B-caryophyllene (BCP) effects were investigated in an in vitro model of glioblastoma. U-373 and U87, derived from a human glioblastoma, and human glioma stem-like cells were treated with BCP at different doses and time-points. [Cancers] Full Article

Cancer Stem Cells in Epstein-Barr Virus-Associated Gastric Carcinoma

Investigators screened previously reported stem cell markers of gastric cancer in Epstein-Barr virus-infected gastric cancer cell lines and identified CD44v6v9 double positive cells as candidate CSCs. [Cancer Sci] Abstract

JAK2 Inhibition in JAK2 V617F-Bearing Leukemia Cells Enriches CD34⁺ Leukemic Stem Cells that Are Abolished by the Telomerase Inhibitor GRN163L

Researchers determined the effect of the specific JAK2V617F inhibitor LY2784544 on leukemic stem cells using the JAK2V617F-bearing erythroleukemia cell line HEL. [Biochem Biophys Res Commun] Abstract

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Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

The authors review the role of H. pylori and its virulence factors in epithelial-mesenchymal transition associated with malignant transformation within the gastric stroma. [Cells] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

MediciNova Receives Notice of Allowance for Second Patent Covering MN-166 (Ibudilast) for the Treatment of Glioblastoma

MediciNova, Inc. announced that it has received a Notice of Allowance from the US Patent and Trademark Office for a pending patent application which covers MN-166 for the treatment of glioblastoma. [MediciNova, Inc.] Press Release

Rafael Pharmaceuticals Receives Approvals to Open Trial Sites in India and Canada for Pivotal Phase III Trial (ARMADA 2000) of CPI-613^® (Devimistat) in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Rafael Pharmaceuticals, Inc. announced that the Central Drugs Standard Control Organization granted approval for the opening of sites in India for the company’s Phase III clinical trial in the treatment of AML. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release

As COVID-19 Forces Conferences Online, Scientists Discover Upsides of Virtual Format

As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunities- for reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. [ScienceInsider] Editorial

Open Science Takes On the Coronavirus Pandemic

When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find. [Nature News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Fellowship – Leukemia Stem Cell Research (Josep Carreras Leukaemia Research Institute)

PhD Positions – Head and Neck Cancer Stem Cells (The Mildred Scheel Nachwuchszentrum for Cancer Research)

Scientist – Stem Cells and Cellular Biology (Athersys, Inc.)

Postdoctoral Positions – DNA Repair in Leukemia (Temple University School of Medicine)

Associate Professor – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Position – Glioma Epigenomic Research (NIH National Cancer Institute)

Postdoctoral Fellow – RAS Proteins and Cancer Cell Stemness (University of Luxembourg)

Postdoctoral Position – Leukemia and Cancer Stemness (Moores Cancer Center, UC San Diego)

Research Fellow – Leukemia Stem Cell Research (Dana Farber Cancer Institute)

Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine)

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