|Cancer Stem Cell News 9.16 April 29, 2020|
Yes-associated protein 1 was highly upregulated in peritoneal carcinomatosis tumor cells, conferred CSC properties and appeared to be a metastatic driver. [Gut]
Scientists report the enrichment of LGR5 expressing cells, a well-recognized stem cell marker in mouse liver tumors, and the upregulation of LGR5 expression in human hepatocellular carcinoma. [Nat Commun]
The authors discovered a significant increase in RNA binding activity of MUSASHI-2 9 (MSI2) in leukemic stem cells compared with normal hematopoietic stem and progenitor cells, resulting in selective regulation of MSI2’s oncogenic targets. [Nat Commun]
Nanog levels were significantly higher in CD44+ head and neck squamous cell carcinomas spheroids than in CD44– spheroids, and further increased when grown as spheroids to enrich for CSCs. [Cell Death Dis]
Autoschizis-like products (ALPs) were found to be specifically engulfed by macrophages expressing a tumor-associated macrophage (TAM) marker CD204. ALPs from glioma stem cells (GSCs) had higher activity for the TAM development than those from non-GSCs. [Stem Cells]
B-caryophyllene (BCP) effects were investigated in an in vitro model of glioblastoma. U-373 and U87, derived from a human glioblastoma, and human glioma stem-like cells were treated with BCP at different doses and time-points. [Cancers]
Investigators screened previously reported stem cell markers of gastric cancer in Epstein-Barr virus-infected gastric cancer cell lines and identified CD44v6v9 double positive cells as candidate CSCs. [Cancer Sci]
Researchers determined the effect of the specific JAK2V617F inhibitor LY2784544 on leukemic stem cells using the JAK2V617F-bearing erythroleukemia cell line HEL. [Biochem Biophys Res Commun]
The authors review the role of H. pylori and its virulence factors in epithelial-mesenchymal transition associated with malignant transformation within the gastric stroma. [Cells]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
MediciNova, Inc. announced that it has received a Notice of Allowance from the US Patent and Trademark Office for a pending patent application which covers MN-166 for the treatment of glioblastoma. [MediciNova, Inc.]
Rafael Pharmaceuticals Receives Approvals to Open Trial Sites in India and Canada for Pivotal Phase III Trial (ARMADA 2000) of CPI-613® (Devimistat) in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)
Rafael Pharmaceuticals, Inc. announced that the Central Drugs Standard Control Organization granted approval for the opening of sites in India for the company’s Phase III clinical trial in the treatment of AML. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]
As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunities- for reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. [ScienceInsider]
When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find. [Nature News]
In light of COVID-19, many conferences are being cancelled or postponed. As such:
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