Cord Blood News 12.19 May 21, 2020 | |
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TOP STORYInvestigators describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more than three kilobases of exogenous DNA in the genome of human MSCs derived from the bone marrow, adipose tissue, and umbilical cord blood without altering their ex vivo characteristics. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)3D-printed poly(lactide-co -glycolide) (PLGA) scaffolds modified with human umbilical cord MSC-derived extracellular matrix (PLGA-ECM) were prepared by a facile tissue engineering technique with physical decellularization and 2.44 ± 0.29 mg cm−3 proteins immobilized on the PLGA-ECM contain multiple soluble cytokines with a sustainable release profile. [Adv Healthc Mater] Abstract Investigators selected placentas from 35 informed donors and exploited three commonly used methods. MSCs were isolated from different parts of placental tissue including umbilical cord, amniotic membrane, chorionic membrane, chorionic villi, and deciduae. [Stem Cell Res Ther] Full Article The authors evaluated the effects and mechanism of tetramethylpyrazine (TMP) on H2O2-stimulated human umbilical cord MSCs (hUCMSCs) and then further investigated the therapeutic effects of TMP-stimulated hUCMSCs on experimental autoimmune encephalomyelitis mice. [Stem Cell Res Ther] Full Article The effects of human umbilical cord MSC-derived exosomes on myocardial pathology injury, proinflammatory cytokines and cardiac function were evaluated through haematoxylin and eosin staining, quantitative polymerase chain reaction and Doppler echocardiography. [J Cell Mol Med] Full Article Scientists retrospectively analyzed community-acquired respiratory virus infections in 216 single-unit myeloablative umbilical cord blood transplantation recipients. [Bone Marrow Transplant] Full Article To investigate which reduced-intensity conditioning (RIC)/reduced-toxicity conditioning (RTC) was superior for umbilical cord blood transplantation for lymphoid malignancies, researchers retrospectively compared three widely used RIC/RTC regimens. [Bone Marrow Transplant] Abstract Hearts transplanted with 2′-deoxycytidine-treated umbilical cord (UC)-MSCs significantly improved the cardiac systolic and diastolic functions and pumping ability as compared to normal UC-MSCs and myocardial infarction groups. [Mol Cell Biochem] Abstract Researchers purified the recombinant AavLEA1 proteins, examined their thermal solubility and the effect of AavLEA1 proteins on the osmotic stress of cells, and studied the effects of the AavLEA1 protein on cryopreservation of human umbilical cord matrix MSCs. [Biopreserv Biobank] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSMechanistic Basis of Ex Vivo Umbilical Cord Blood Stem Progenitor Cell Expansion Scientists address the methods that promote ex vivo cord blood expansion within the context of symmetrical and asymmetrical hematopoietic stem cell division and those that rely on epigenetic mechanisms, along with the reportedly most successful cytokine combinations. [Stem Cell Rev Rep] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSFDA Approves COVID-19 Trial after Successful Emergency Use of Umbilical Stem Cells from RESTEM RESTEM announced it has received approval from the FDA for a 60-patient Phase I/IIa study using umbilical cord MSCs to treat patients with severe cases of COVID-19. [RESTEM (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWill Trump White House Tear Down Journal Paywalls? Many Anxiously Await a Decision Scientific publishers, universities, librarians, and open-access advocates are waiting anxiously to see whether the Trump administration will end a long-standing policy and require that every scholarly article produced with US funding be made immediately free to all. [ScienceInsider] Editorial Are Women Publishing Less during the Pandemic? Here’s What the Data Say Early analyses suggest that female academics are posting fewer preprints and starting fewer research projects than their male peers. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine) Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital) Head – Hematological Cancer (Ichnos) Postdoctoral Position – Tumor Immunology (University of Maryland) Senior Scientist – Cell Engineering (Merck & Co., Inc.) Project Manager – Precision Medicine (Prinses Máxima Centrum) Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute) Director – Blood Research Institute (Versiti) Postdoctoral Positions – Leukemia (Temple University School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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