Cord Blood News Volume 12.20 | May 28 2020

TOP STORY

Putative Regulators for the Continuum of Erythroid Differentiation Revealed by Single-Cell Transcriptome of Human BM and UCB Cells

Using single-cell RNA sequencing of primary human terminal erythroid cells isolated directly from adult bone marrow (BM) and umbilical cord blood (UCB), researchers documented the transcriptome of terminally differentiated human erythroblasts at unprecedented resolution. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

Exosomal miRNA-17-5p Derived from Human Umbilical Cord Mesenchymal Stem Cells Improves Ovarian Function in Premature Ovarian Insufficiency by Regulating SIRT7

Researchers illustrated that human-umbilical cord mesenchymal stem cell-derived exosomes (hUMSC-Exos) restored ovarian phenotype and function in a premature ovarian insufficiency mouse model, promoted proliferation of cyclophosphamide-damaged human granulosa cells and ovarian cells, and alleviated ROS accumulation by delivering exosomal miR-17-5P and inhibiting SIRT7 expression. [Stem Cells] Abstract

Cord Blood Low-Density Granulocytes Correspond to an Immature Granulocytic Subset with Low Expression of S100A12

Scientists characterized cord blood-low-density granulocytes as immature neutrophils with functional deficits and decreased expression and storage of S100A12. [J Immunol] Abstract

Intravenous Infusion of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells as a Potential Treatment for Patients with COVID-19 Pneumonia

Investigators report a case of a severe COVID-19 patient treated with human umbilical cord Wharton’s jelly-derived MSCs from a healthy donor. [Stem Cell Res Ther] Full Article

Three-dimensional Culture of MSCs Produces Exosomes with Improved Yield and Enhanced Therapeutic Efficacy for Cisplatin-Induced Acute Kidney Injury

In vivo, both 2D-exosomes (exos) and 3D-exos significantly alleviated cisplatin-induced murine acute kidney injury evidenced by improved renal function, attenuated pathological changes of renal tubules, reduced inflammatory factors, and repressed T cell and macrophage infiltration. [Stem Cell Res Ther] Full Article

VX-765 Enhances Autophagy of Human Umbilical Cord Mesenchymal Stem Cells against Stroke-Induced Apoptosis and Inflammatory Responses via AMPK/mTOR Signaling Pathway

VX-765 protected human umbilical MSCs against stroke‐induced apoptosis and inflammatory responses by activating autophagy via the AMPK/mTOR signaling pathway in vivo and in vitro. [CNS Neurosci Ther] Full Article

Immune Reconstitution following Umbilical Cord Blood Transplantation: IRES, a Study of UK Paediatric Patients

To obtain a qualitative as well as quantitative view immune reconstitution following umbilical cord blood transplantation of paediatric patients, researchers utilized a broad panel of flow cytometry markers to monitor the phenotypes of lymphoid and myeloid cells at 1-12 months post-transplant. [eJHaem] Full Article

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Hematopoietic Stem Cell Self-Renewal In Vivo and Ex Vivo

The authors present their current understanding of hematopoietic stem cell (HSC) self-renewal in vivo and ex vivo, and discuss important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities. [Nat Rev Genet] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

MacroGenics Announces Registration Study of Flotetuzumab in Patients with Refractory Acute Myeloid Leukemia

MacroGenics, Inc. announced plans for a clinical study intended to support registration in the US of flotetuzumab, an investigational, bispecific CD123 x CD3 DART^® molecule for patients with acute myeloid leukemia who are refractory to induction therapy. [MacroGenics, Inc.] Press Release

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

What the Growing Rift Between the US and WHO Means for COVID-19 and Global Health

Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial

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NEW Professor – Hematology-Oncology (Karolinska Institutet)

Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Department Head – Hematological Cancer (Ichnos)

Deputy Director – Division of Blood Diseases and Resources (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Senior Scientist – Cell Engineering (Merck & Co., Inc.)

Project Manager – Precision Medicine (Prinses Máxima Centrum)

Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute)

Director – Blood Research Institute (Versiti)

Postdoctoral Positions – Leukemia (Temple University School of Medicine)

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