Cord Blood News 12.20 May 28, 2020 | |
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TOP STORYUsing single-cell RNA sequencing of primary human terminal erythroid cells isolated directly from adult bone marrow (BM) and umbilical cord blood (UCB), researchers documented the transcriptome of terminally differentiated human erythroblasts at unprecedented resolution. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers illustrated that human-umbilical cord mesenchymal stem cell-derived exosomes (hUMSC-Exos) restored ovarian phenotype and function in a premature ovarian insufficiency mouse model, promoted proliferation of cyclophosphamide-damaged human granulosa cells and ovarian cells, and alleviated ROS accumulation by delivering exosomal miR-17-5P and inhibiting SIRT7 expression. [Stem Cells] Abstract Scientists characterized cord blood-low-density granulocytes as immature neutrophils with functional deficits and decreased expression and storage of S100A12. [J Immunol] Abstract Investigators report a case of a severe COVID-19 patient treated with human umbilical cord Wharton’s jelly-derived MSCs from a healthy donor. [Stem Cell Res Ther] Full Article In vivo, both 2D-exosomes (exos) and 3D-exos significantly alleviated cisplatin-induced murine acute kidney injury evidenced by improved renal function, attenuated pathological changes of renal tubules, reduced inflammatory factors, and repressed T cell and macrophage infiltration. [Stem Cell Res Ther] Full Article VX-765 protected human umbilical MSCs against stroke‐induced apoptosis and inflammatory responses by activating autophagy via the AMPK/mTOR signaling pathway in vivo and in vitro. [CNS Neurosci Ther] Full Article To obtain a qualitative as well as quantitative view immune reconstitution following umbilical cord blood transplantation of paediatric patients, researchers utilized a broad panel of flow cytometry markers to monitor the phenotypes of lymphoid and myeloid cells at 1-12 months post-transplant. [eJHaem] Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSHematopoietic Stem Cell Self-Renewal In Vivo and Ex Vivo The authors present their current understanding of hematopoietic stem cell (HSC) self-renewal in vivo and ex vivo, and discuss important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities. [Nat Rev Genet] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSMacroGenics, Inc. announced plans for a clinical study intended to support registration in the US of flotetuzumab, an investigational, bispecific CD123 x CD3 DART® molecule for patients with acute myeloid leukemia who are refractory to induction therapy. [MacroGenics, Inc.] Press Release | |
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POLICY NEWSUS Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial What the Growing Rift Between the US and WHO Means for COVID-19 and Global Health Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Professor – Hematology-Oncology (Karolinska Institutet) Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine) Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital) Department Head – Hematological Cancer (Ichnos) Postdoctoral Position – Tumor Immunology (University of Maryland) Senior Scientist – Cell Engineering (Merck & Co., Inc.) Project Manager – Precision Medicine (Prinses Máxima Centrum) Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute) Director – Blood Research Institute (Versiti) Postdoctoral Positions – Leukemia (Temple University School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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