| Vol. 12.23 – 16 June, 2020 |
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| The authors describe a highly osteogenic MSC line generated from induced pluripotent stem cells that generated high yields of an osteogenic cell-matrix in vitro. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Through the optimization of material properties and composition of incubation buffers, silk ionomers could be electrostatically assembled on the surface of murine fibroblasts and human mesenchymal stem cells to form nanoscale multilayers without significantly impairing cell viability. [Biomacromolecules] |
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| Stem cells isolated from rat femora were incorporated into poly-l-lactide acid (PLLA) and PLLA-collagen type-I nanofiber scaffolds via simultaneous electrospinning and spraying. [Scientific Reports] |
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| Two types of bone-derived cells were used for a biocompatibility assessment. While no increase in cell membrane damage, in ROS generation and in TNF-alpha secretion of bone-derived cells grown on both silicalite-1 films was found. [Scientific Reports] |
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| A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct. [Macromolecular Bioscience] |
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| Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis. [Cell Biology and Toxicology] |
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| Systemic Notch inhibition using diabenzazepine reduced bone morphogenetic protein (BMP)2-induced calvarial bone healing in mice supporting the critical regulatory role of Notch signaling in BMP-induced osteoblastogenesis. [Stem Cells] |
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| Investigators generated bobby sox homolog (Bbx) knockout mice to address the functional role of Bbx in tooth formation. During tooth development, Bbx was expressed in both dental epithelium and mesenchyme. [Journal of Cellular Physiology] |
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| Researchers performed unilateral open transverse tibial fracture procedure in C57BL/6 mice which were treated with or without Bushenhuoxue formula. [Phytomedicine] |
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| Researchers evaluated the process of osteoclastogenesis and observed that conditioned media from Gaucher disease MSCs supernatants induced an increase in the number of osteoclasts. [Molecular Genetics and Metabolism] |
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| Chordomas and chondrosarcomas are not sensitive to chemotherapy and there are no approved drugs for their treatment. The present treatment concept is a combination of surgical resection with a maximal excision and preserving patients’ quality of life by adjuvant radiotherapy for both, chordomas and chondrosarcomas. [Neuroendocrinology] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected. [Nature News] |
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| The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022. [ScienceInsider] |
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CyMedica Orthopedics announced that it completed early enrollment of 159 patients in the FDA-regulated clinical trial of their e-vive technology for pain relief in patients with knee osteoarthritis. [CyMedica Orthopedics] |
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| 2020-10-12 – 2020-10-14 Paris, France | |
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| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| University of Copenhagen – Copenhagen, Denmark |
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| Fondazione Banca dei Tessuti di Treviso Onlus – Treviso, Italy |
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| Institut Pasteur of Shanghai – Shanghai, China |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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| Tulane University School of Medicine – New Orleans, Louisiana, United States |
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| KU Leuven – Leuven, Belgium |
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| Radboud umc – Nijmegen, Netherlands |
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