Neural Cell News Volume 14.20 | May 27 2020

TOP STORY

Structures of α-Synuclein Filaments from Multiple System Atrophy

Investigators showed that α-synuclein inclusions from the brains of individuals with multiple system atrophy were made of two types of filament, each of which consisted of two different protofilaments. [Nature] Abstract

(Ranked by impact factor of the journal)

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function

The authors performed rapid structured illumination microscopy and enhanced resolution confocal microscopy to study spatiotemporal spinule dynamics in cortical pyramidal neurons. [Neuron] Abstract | Graphical Abstract | Press Release

hnRNP H/F Drive RNA G-Quadruplex-Mediated Translation Linked to Genomic Instability and Therapy Resistance in Glioblastoma

Scientists performed a quantitative proteomic screen to identify cytosolic proteins that interacted with a canonical RNA G-quadruplexes in its folded and unfolded conformation. [Nat Commun] Full Article

Inhibition of SETMAR-H3K36me2-NHEJ Repair Axis in Residual Disease Cells Prevent Glioblastoma Recurrence

Molecular signaling of resistance in therapy resistant residual cells was identified using RNA sequencing, genetic and pharmacological perturbations, overexpression systems, molecular and biochemical assays. [Neuro Oncol] Abstract

Fine Tuning of the Unfolded Protein Response by ISRIB Improves Neuronal Survival in a Model of Amyotrophic Lateral Sclerosis

Inhibition of PKR-like endoplasmic reticulum kinase (PERK) signaling with its downstream inhibitor ISRIB, but not with the direct PERK kinase inhibitor GSK2606414, significantly enhanced the survival of G93A SOD1-expressing neurons. [Cell Death Dis] Full Article

LncRNA SOX2OT Promotes Temozolomide Resistance by Elevating SOX2 Expression via ALKBH5-Mediated Epigenetic Regulation in Glioblastoma

Scientists found that LncRNA SOX2OT was increased in temozolomide-resistant cells and recurrent glioblastoma patient samples, and abnormal expression was correlated with high risk of relapse and poor prognosis. [Cell Death Dis] Full Article

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture

Researchers demonstrated that co-culture of microglia-like cell precursors with human glia and neurons enhanced transcriptional resemblance of microglia-like cells to ex vivo microglia. [Stem Cell Reports] Full Article

Sustained Hedgehog Signaling in Medulloblastoma Tumoroids Is Attributed to Stromal Astrocytes and Astrocyte-Derived Extracellular Matrix

The authors demonstrated that medulloblastoma cells were capable of forming tumor spheroids in vitro under optimized conditions, which could be further passaged and cryopreserved. [Lab Invest] Abstract

Inhibition of miR-181a-5p Reduces Astrocyte and Microglia Activation and Oxidative Stress by Activating SIRT1 in Immature Rats with Epilepsy

Inhibition of miR-181a-5p protected the hippocampus against epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, oxidative stress, mitochondrial function, and cognitive dysfunction. [Lab Invest] Abstract

Avasimibe Exerts Anticancer Effects on Human Glioblastoma Cells via Inducing Cell Apoptosis and Cell Cycle Arrest

Scientists investigated the anticancer effects of avasimibe on human glioblastoma cells and the underlying mechanisms. [Acta Pharmacol Sin] Abstract

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GAD Antibodies in Neurological Disorders – Insights and Challenges

The authors provide recommendations for assessing the association between a neurological syndrome and the presence of glutamic acid decarboxylase (GAD) antibodies, and they critically review the evidence on the pathogenicity of GAD antibodies. [Nat Rev Neurol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

Triplet Therapeutics Initiates SHIELD HD Natural History Study of Huntington’s Disease

Triplet Therapeutics, Inc. announced it has initiated a natural history study of Huntington’s disease to assess clinical outcomes and biomarkers that will inform upcoming interventional clinical trials. [Triplet Therapeutics, Inc. (BusinessWire, Inc.)] Press Release

Bristol Myers Squibb Receives European Commission Approval for Zeposia (Ozanimod) for the Treatment of Adult Patients with Relapsing Remitting Multiple Sclerosis with Active Disease

Bristol Myers Squibb announced that the European Commission has approved Zeposia for the treatment of adult patients with relapsing remitting multiple sclerosis with active disease as defined by clinical or imaging features. [Bristol Myers Squibb] Press Release

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

They Redesigned PubMed, a Beloved Website. It Hasn’t Gone Over Well

Unfortunately for PubMed’s caretakers, a sweeping redesign unveiled this week has left many PubMed users fuming-and airing their sometimes curse-laden complaints on social media. [ScienceInsider] Editorial

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NEW Postdoctoral Fellow – Genes in Neural Circuits (Cold Spring Harbor Laboratory)

Postdoctoral Position – Electron Microscopy of Brain Circuits (Technical University of Munich)

Investigator Scientist – Brain Neuron Research (The MRC Laboratory of Molecular Biology)

Postdoctoral Position – Ferroptosis Research in Neuroblastoma (Flanders Institute for Biotechnology)

Postdoctoral Associate – Neurobiology Research (Cornell University)

Postdoctoral Position – Neuroscience (Linköping University)

Associate Professor – Molecular Neurobiology (Aarhus University)

Researcher Position – Transcriptional Activity in Brain Diseases (Italian Institute of Technology)

Postdoctoral Position – Brain and Disease Research (Flanders Institute for Biotechnology)

Postdoctoral Fellow – Neurogenerative Disease (Johns Hopkins University School of Medicine)

Postdoctoral Program – Aging and Alzheimer’s Disease Research (Huntington Medical Research Institutes)

Scientist – Oligonucleotide Therapies for Neurological Disorders (Deep Genomics Inc.)

Postdoctoral Associate – Neuron Diversity Mechanisms in Brain Development (Howard Hughes Medical Institute)

Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research)

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