Pancreatic Cell News Volume 11.20 | May 26 2020

TOP STORY

A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line

GATA6 protein expression remained depressed in pancreatic progenitor cells even after correction of the coding mutation. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Protective Effects of Calcineurin on Pancreatitis in Mice Depend on Cellular Source

Mouse and human primary pancreatic acinar cells were transfected with a vector that expressed NFAT-luciferase and incubated with an agent that blocked interaction of NFAT with calcineurin; cells were analyzed by immunofluorescence. [Gastroenterology] Abstract

Raptor Determines β-Cell Identity and Plasticity Independent of Hyperglycemia in Mice

Scientists found that diabetic β-cell specific Raptor-deficient mice showed reduced β-cell mass, loss of β-cell identity and acquisition of α-cell features. [Nat Commun] Full Article

An Integrated Multi-Omics Approach Identifies the Landscape of Interferon-α-Mediated Responses of Human Pancreatic Beta Cells

Interferon-α induced changes in alternative splicing and first exon usage, increasing the diversity of transcripts expressed by the beta cells. [Nat Commun] Full Article

SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

The authors showed that maturation of stem cell-β cells was regulated by the transcription factor SIX2. Knockdown or knockout of SIX2 in stem cell-β cells drastically limited glucose-stimulated insulin secretion in both static and dynamic assays. [Cell Rep] Full Article | Graphical Abstract

PANCREATIC CANCER

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles from Cancer Cells That Promote Metastasis to Lung in Mice

Pancreatic cancer cell lines were analyzed by gene-expression microarray, quantitative PCR, immunoblot, and immunofluorescence analyses. [Gastroenterology] Abstract | Graphical Abstract | Full Article

Holliday Junction Recognition Protein Promotes Pancreatic Cancer Growth and Metastasis via Modulation of the MDM2/p53 Signaling

MTT, sphere formation assay, migration, and invasion assays were performed to evaluate the viability, proliferation, migration, and invasion of PDAC cells. [Cell Death Dis] Full Article

The Effect of Ibrutinib on Radiosensitivity in Pancreatic Cancer Cells by Targeting EGFR/AKT/mTOR Signaling Pathway

Human BXPC3 and Capan2 cell lines were treated with ibrutinib, and cell viability was conducted with CCK-8 assay. Researchers revealed that ibrutinib inhibited the proliferation of pancreatic cancer cells. [Biomed Pharmacother] Full Article

Selective Induction of Cellular Toxicity and Anti-Tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and Its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-Cycle Arrest in Human Pancreatic Cancer

Scientists describe the anticancer efficacy of two novel compounds, N-methylpiperazinyl diarylidenylpiperidone and its pro-nitroxide conjugate evaluated on human pancreatic adenocarcinoma cell lines. [Cell Biochem Biophys] Abstract

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SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma

The authors describe the complex role of SMAD4 in the transforming growth factor β (TGFβ) pathway in patients with pancreatic ductal adenocarcinoma . [Int J Mol Sci] Full Article

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PharmaCyte Biotech Announces Final Major Study for IND Submission Has Begun

PharmaCyte Biotech, Inc. announced that the final major study required by the FDA for the submission of PharmaCyte’s Investigational New Drug application (IND) has been initiated. [PharmaCyte Biotech, Inc.] Press Release

$5.75M Grant to Help Researchers Study Role of Obesity in Development of Pancreatic Cancer

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. [UCLA Health] Press Release

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

They Redesigned PubMed, a Beloved Website. It Hasn’t Gone Over Well

Unfortunately for PubMed’s caretakers, a sweeping redesign unveiled this week has left many PubMed users fuming-and airing their sometimes curse-laden complaints on social media. [ScienceInsider] Editorial

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NEW Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer (Klinikum rechts der Isar der Technischen Universität München)

NEW Postdoctoral Research Associate – Tumor Biology (University of Würzburg)

NEW Postdoctoral Associate – Pancreatic Disease Research (University of Miami Health System)

Postdoctoral Fellow – Pancreas and Islet Biology Research (Vanderbilt University Medical Center)

Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University)

Postdoctoral Fellowship – Pancreatic Progenitor Research (University of Copenhagen)

Laboratory Manager – Diabetes (Helmholtz Zentrum München)

Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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