Pancreatic Cell News 11.20 May 26, 2020 | |
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TOP STORYGATA6 protein expression remained depressed in pancreatic progenitor cells even after correction of the coding mutation. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISProtective Effects of Calcineurin on Pancreatitis in Mice Depend on Cellular Source Mouse and human primary pancreatic acinar cells were transfected with a vector that expressed NFAT-luciferase and incubated with an agent that blocked interaction of NFAT with calcineurin; cells were analyzed by immunofluorescence. [Gastroenterology] Abstract Raptor Determines β-Cell Identity and Plasticity Independent of Hyperglycemia in Mice Scientists found that diabetic β-cell specific Raptor-deficient mice showed reduced β-cell mass, loss of β-cell identity and acquisition of α-cell features. [Nat Commun] Full Article Interferon-α induced changes in alternative splicing and first exon usage, increasing the diversity of transcripts expressed by the beta cells. [Nat Commun] Full Article SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro The authors showed that maturation of stem cell-β cells was regulated by the transcription factor SIX2. Knockdown or knockout of SIX2 in stem cell-β cells drastically limited glucose-stimulated insulin secretion in both static and dynamic assays. [Cell Rep] Full Article | Graphical Abstract PANCREATIC CANCERPancreatic cancer cell lines were analyzed by gene-expression microarray, quantitative PCR, immunoblot, and immunofluorescence analyses. [Gastroenterology] Abstract | Graphical Abstract | Full Article MTT, sphere formation assay, migration, and invasion assays were performed to evaluate the viability, proliferation, migration, and invasion of PDAC cells. [Cell Death Dis] Full Article Human BXPC3 and Capan2 cell lines were treated with ibrutinib, and cell viability was conducted with CCK-8 assay. Researchers revealed that ibrutinib inhibited the proliferation of pancreatic cancer cells. [Biomed Pharmacother] Full Article Scientists describe the anticancer efficacy of two novel compounds, N-methylpiperazinyl diarylidenylpiperidone and its pro-nitroxide conjugate evaluated on human pancreatic adenocarcinoma cell lines. [Cell Biochem Biophys] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSSMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma The authors describe the complex role of SMAD4 in the transforming growth factor β (TGFβ) pathway in patients with pancreatic ductal adenocarcinoma . [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSPharmaCyte Biotech Announces Final Major Study for IND Submission Has Begun PharmaCyte Biotech, Inc. announced that the final major study required by the FDA for the submission of PharmaCyte’s Investigational New Drug application (IND) has been initiated. [PharmaCyte Biotech, Inc.] Press Release $5.75M Grant to Help Researchers Study Role of Obesity in Development of Pancreatic Cancer A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. [UCLA Health] Press Release | |
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POLICY NEWSUS Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial They Redesigned PubMed, a Beloved Website. It Hasn’t Gone Over Well Unfortunately for PubMed’s caretakers, a sweeping redesign unveiled this week has left many PubMed users fuming-and airing their sometimes curse-laden complaints on social media. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Associate – Tumor Biology (University of Würzburg) NEW Postdoctoral Associate – Pancreatic Disease Research (University of Miami Health System) Postdoctoral Fellow – Pancreas and Islet Biology Research (Vanderbilt University Medical Center) Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University) Postdoctoral Fellowship – Pancreatic Progenitor Research (University of Copenhagen) Laboratory Manager – Diabetes (Helmholtz Zentrum München) Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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