Pancreatic Cell News Volume 11.22 | Jun 9 2020

TOP STORY

An Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development

In mouse and human pancreatic tissues, pancreatic ductal adenocarcinoma progression was associated with increased plasma membrane localization of RAS/Argonaute 2. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Short-term Inhibition of Autophagy Benefits Pancreatic β-Cells by Augmenting Ether Lipids and Peroxisomal Function, and by Countering Depletion of n-3 Polyunsaturated Fatty Acids after Fat-Feeding

β-cell function was impaired by inhibiting autophagy in the longer-term, but conversely improved by three week deletion of Atg7, specifically under high-fat diet conditions. [Mol Metab] Full Article | Graphical Abstract

Stat2 Loss Disrupts Damage Signaling and Is Protective in Acute Pancreatitis

Stat2 deletion in pancreatic and duodenal homeobox 1-expressing acinar cells reduced pancreatic TNFα expression, but not histological injury or serum amylase [J Pathol] Abstract

Ternary Complex Factor Regulates Pancreatic Islet Size and Blood Glucose Homeostasis in Transgenic Mice

Expression of the Elk-1 mutant in pancreatic β-cells resulted in the generation of significantly smaller islets and increased caspase-3 activity, indicating that apoptosis was responsible for the reduction of the pancreatic islet size. [Pharmacol Res] Abstract | Graphical Abstract

PANCREATIC CANCER

Enhanced Efficacy of Combination of Gemcitabine and Phosphatidylserine-Targeted Nanovesicles against Pancreatic Cancer

Scientists observed that gemcitabine treatment preferentially targeted G1 phase cells that had low surface phosphatidylserine (PS), resulting in an increased median surface PS level of pancreatic ductal adenocarcinoma cells. [Mol Ther] Abstract | Graphical Abstract

Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single Cell Transcriptomics Analysis of Circulating Tumor Cells

Researchers describe the generation of highly metastatic pancreatic ductal adenocarcinoma patient-derived xenograft mouse models and subsequent single-cell RNA sequencing of circulating tumor cells, isolated by human HLA sorting. [Mol Cancer Ther] Abstract

PAWI-2 Overcomes Tumor Stemness and Drug Resistance via Cell Cycle Arrest in Integrin β₃-KRAS-Dependent Pancreatic Cancer Stem Cells

Compared to parental bulk FG cells, PAWI-2 showed greater potency to inhibit cell viability and self-renewal capacity of FGβ₃ cells. [Sci Rep] Full Article

R269C Variant of ESR1: High Prevalence and Differential Function in a Subset of Pancreatic Cancers

R269C-estrogen receptor α (ESR1) enhanced E2-response elements (ERE) and AP1-dependent transcriptional activity and increased mRNA levels of ERE and AP1-regulated genes in pancreatic cancer cell lines. [BMC Cancer] Full Article

The Effects of NLRP3 Inflammasome Inhibition by MCC950 on LPS-induced Pancreatic Adenocarcinoma Inflammation

LPS-induced inflammation in the presence of ATP activated NLRP3 that subsequently increased pancreatic cancer cell proliferation by increasing caspase-1 activity leading to overall production of IL-1β. [J Cancer Res Clin Oncol] Abstract

LncRNA ZEB1-AS1 Promotes Pancreatic Cancer Progression by Regulating miR-505-3p/TRIB2 Axis

CCK-8 assay was employed to analyze pancreatic cancer cell viability. Transwell assay was employed to detect the migration and invasion of pancreatic cancer cells. [Biochem Biophys Res Commun] Abstract

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Protein Tyrosine Phosphatase 1B Inhibition as a Potential Therapeutic Target for Chronic Wounds in Diabetes

The pharmacological modulation of protein tyrosine phosphatase 1B (PTP1B) activity may help treat diabetic foot ulcers, suggesting that PTP1B inhibition was an outstanding therapeutic target. [Pharmacol Res] Abstract | Graphical Abstract

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LYNPARZA^® (Olaparib) Receives Positive Opinion from EU CHMP for First-Line Maintenance Treatment of Patients with Germline BRCA-Mutated Metastatic Pancreatic Cancer

AstraZeneca and Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion, recommending LYNPARZA for approval as monotherapy for the maintenance treatment of adult patients with germline BRCA1/2 mutations who have metastatic adenocarcinoma of the pancreas. [Merck] Press Release

As Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat

This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial

As the Pandemic Hits Campus Finances, Faculty Face Layoffs

The pandemic has bored holes in budgets at universities and colleges across the US and beyond. To stem the spread of the coronavirus, higher education institutions shuttered their campuses, sent students home, and moved classes online. [The Scientist] Editorial

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NEW Senior Investigator – Electron Micrscopy Research (NIH National Cancer Institute)

PhD Student – Pancreatic Cancer (University College Dublin)

Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer (Klinikum rechts der Isar der Technischen Universität München)

Postdoctoral Research Associate – Tumor Biology (University of Würzburg)

Postdoctoral Associate – Pancreatic Disease Research (University of Miami Health System)

Postdoctoral Fellow – Pancreas and Islet Biology Research (Vanderbilt University Medical Center)

Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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