Prostate Cell News Volume 11.19 | May 29 2020

TOP STORY

LncRNA SNHG17 Aggravated Prostate Cancer Progression through Regulating Its Homolog SNORA71B via a Positive Feedback Loop

Small nucleolar host gene (SNHG)17 and small nucleolar RNA (SNORA)71B were transcriptionally activated by signal transducer and activator of transcription 5A. SNHG17 positively regulated SNORA71B in prostate cancer cell lines and other cell lines. [Cell Death Dis] Full Article

(Ranked by impact factor of the journal)

Targeting RET Kinase in Neuroendocrine Prostate Cancer

Scientists performed global phosphoproteomics comparing several androgen receptor (AR) independent to AR dependent prostate cancer cell lines and identified multiple altered signaling pathways, including enrichment of RET kinase activity in the AR independent cell lines. [Mol Cancer Res] Abstract

CUDC-907, a Novel Dual PI3K and HDAC Inhibitor, in Prostate Cancer: Antitumor Activity and Molecular Mechanism of Action

The authors demonstrated that the novel dual PI3K and histone deacetylase inhibitor CUDC-907 had promising antitumor activity against prostate cancer cell lines in vitro. [J Cell Mol Med] Full Article

MicroRNA-1271 Impedes the Development of Prostate Cancer by Downregulating PES1 and Upregulating ERβ

Pescadillo homolog 1 (PES1) was identified as a prostate cancer-related differentially expressed gene and found to be upregulated in prostate cancer. miR-1271 was poorly expressed in both cells and tissues of prostate cancer, and could specifically bind to PES1. [J Transl Med] Full Article

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

Amorphigenin, dalpanol, dihydroamorphigenin, and amorphigenol were selected and evaluated in cell-based assays using C4-2 and C4-2B prostate cancer cells alongside control PNT2 prostate cells. [J Nat Prod] Abstract | Graphical Abstract

Independence of HIF1a and Androgen Signaling Pathways in Prostate Cancer

In vitro stable expression of HIF1a was established in the LNCaP cell line by physiological induction or retroviral transduction. [BMC Cancer] Full Article

SHCBP1 Promotes Tumor Cell Proliferation, Migration, and Invasion, and Is Associated with Poor Prostate Cancer Prognosis

Lentivirus-mediated shRNA knockdown of SH2-domain-binding protein 1 (SHCBP1) in prostate cancer cell lines diminished cell growth, migration, and invasion dramatically both in vitro and in vivo. [J Cancer Res Clin Oncol] Abstract

Prostate Cancer Cell Phenotypes Remain Stable following PDE5 Inhibition in the Clinically Relevant Range

Prostate cancer cell lines were treated with phosphodiesterase 5 inhibitors at clinically relevant concentrations. [Transl Oncol] Abstract

Evaluation of Somatostatin and CXCR4 Receptor Expression in a Large Set of Prostate Cancer Samples Using Tissue Microarrays and Well-Characterized Monoclonal Antibodies

Independent of the tumor cells, the tumor capillaries in many of the prostate cancer samples were strongly positive for somatostatin receptor (SST)2A, SST3, SST5, or CXCR4 expression. [Transl Oncol] Full Article

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Photodynamic Diagnosis and Therapy for Urothelial Carcinoma and Prostate Cancer: New Imaging Technology and Therapy

The authors summarize the clinical outcomes of photodynamic diagnosis and photodynamic therapy for urothelial carcinoma and prostate cancer. [Int J Clin Oncol] Abstract

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Clovis Oncology Announces New Recommendations for Rubraca^® (Rucaparib) Tablets in Updated National Comprehensive Cancer Network (NCCN) Guidelines^® for the Treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Clovis Oncology, Inc. announced that Rubraca is now recommended in the NCCN Guidelines^® for the treatment of BRCA-mutant patients with mCRPC under second-line treatment. [Clovis Oncology, Inc.] Press Release

US Looks to Block Chinese Grad Students’ and Researchers’ Visas

Administration officials and lawmakers say the move is to shore up national security threats, but university professors argue such cancellations represent targeted discrimination. [The Scientist] Editorial

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

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NEW Postdoctoral Position – 3D Genome Organization in Prostate Cancer (Karolinska Institutet)

Postdoctoral Fellow – Prostate Cancer Research (The Vita-Salute San Raffaele University)

Postdoctoral Fellow – Cancer Metabolism Research (Augusta University)

Postdoctoral Fellowship – Molecular Mechanisms in Prostate Cancer (Cleveland Clinic)

Doctoral Student – Prostate Cancer (Karolinska Institutet)

Associate Professor – Prostate Disease Research (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Position – Prostate Cancer (University of Washington)

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