Prostate Cell News 11.19 May 29, 2020 | |
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TOP STORYSmall nucleolar host gene (SNHG)17 and small nucleolar RNA (SNORA)71B were transcriptionally activated by signal transducer and activator of transcription 5A. SNHG17 positively regulated SNORA71B in prostate cancer cell lines and other cell lines. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Targeting RET Kinase in Neuroendocrine Prostate Cancer Scientists performed global phosphoproteomics comparing several androgen receptor (AR) independent to AR dependent prostate cancer cell lines and identified multiple altered signaling pathways, including enrichment of RET kinase activity in the AR independent cell lines. [Mol Cancer Res] Abstract The authors demonstrated that the novel dual PI3K and histone deacetylase inhibitor CUDC-907 had promising antitumor activity against prostate cancer cell lines in vitro. [J Cell Mol Med] Full Article Pescadillo homolog 1 (PES1) was identified as a prostate cancer-related differentially expressed gene and found to be upregulated in prostate cancer. miR-1271 was poorly expressed in both cells and tissues of prostate cancer, and could specifically bind to PES1. [J Transl Med] Full Article Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells Amorphigenin, dalpanol, dihydroamorphigenin, and amorphigenol were selected and evaluated in cell-based assays using C4-2 and C4-2B prostate cancer cells alongside control PNT2 prostate cells. [J Nat Prod] Abstract | Graphical Abstract Independence of HIF1a and Androgen Signaling Pathways in Prostate Cancer In vitro stable expression of HIF1a was established in the LNCaP cell line by physiological induction or retroviral transduction. [BMC Cancer] Full Article Lentivirus-mediated shRNA knockdown of SH2-domain-binding protein 1 (SHCBP1) in prostate cancer cell lines diminished cell growth, migration, and invasion dramatically both in vitro and in vivo. [J Cancer Res Clin Oncol] Abstract Prostate cancer cell lines were treated with phosphodiesterase 5 inhibitors at clinically relevant concentrations. [Transl Oncol] Abstract Independent of the tumor cells, the tumor capillaries in many of the prostate cancer samples were strongly positive for somatostatin receptor (SST)2A, SST3, SST5, or CXCR4 expression. [Transl Oncol] Full Article Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News. | |
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REVIEWSThe authors summarize the clinical outcomes of photodynamic diagnosis and photodynamic therapy for urothelial carcinoma and prostate cancer. [Int J Clin Oncol] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSClovis Oncology, Inc. announced that Rubraca is now recommended in the NCCN Guidelines® for the treatment of BRCA-mutant patients with mCRPC under second-line treatment. [Clovis Oncology, Inc.] Press Release | |
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POLICY NEWSUS Looks to Block Chinese Grad Students’ and Researchers’ Visas Administration officials and lawmakers say the move is to shore up national security threats, but university professors argue such cancellations represent targeted discrimination. [The Scientist] Editorial US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – 3D Genome Organization in Prostate Cancer (Karolinska Institutet) Postdoctoral Fellow – Prostate Cancer Research (The Vita-Salute San Raffaele University) Postdoctoral Fellow – Cancer Metabolism Research (Augusta University) Postdoctoral Fellowship – Molecular Mechanisms in Prostate Cancer (Cleveland Clinic) Doctoral Student – Prostate Cancer (Karolinska Institutet) Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet) Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation) Postdoctoral Position – Prostate Cancer (University of Washington) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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