Pulmonary Cell News Volume 9.18 | May 14 2020

TOP STORY

Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-Fibrotic Effects by Inhibiting MRTF-A/SRF Signaling

The authors found that miR-1193-3p, miR-411-3p and miR-370-3p exhibited potent anti-fibrotic effects while miR-292-5p demonstrated pro-fibrotic effects in TGF-β1-stimulated lung fibroblasts. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Human Multi-Organ Chip Co-Culture of Bronchial Lung Culture and Liver Spheroids for Substance Exposure Studies

Scientists co-cultured a human lung equivalent from the commercially available bronchial MucilAir culture and human liver spheroids from HepaRG cells to assess the potential toxicity of inhaled substances under conditions that permit organ crosstalk. [Sci Rep] Full Article

Respiratory Exposure to PM2.5 Soluble Extract Disrupts Mucosal Barrier Function and Promotes the Development of Experimental Asthma

Soluble PM2.5 extract exposure in vitro decreased the viability and increased apoptosis of airway epithelial cells. [Sci Total Environ] Abstract | Graphical Abstract

LUNG CANCER

The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure

To study the molecular/cellular mechanisms of increased resistance of non-small cell lung cancer (NSCLC) to ionizing radiation exposure, researchers compared A549 and H1299 cells, the two NSCLC cell lines. [Int J Mol Sci] Full Article

Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

Researchers found that micheliolide (MCL) exerted a tumor cell killing effect on non-small-cell lung cancer (NSCLC) cells in a dose-dependent manner, and MCL strongly sensitized p53-deficient NSCLC cells, but not the cells with wild-type p53 to irradiation. [Int J Mol Sci] Full Article

HKB99, an Allosteric Inhibitor of Phosphoglycerate Mutase 1, Suppresses Invasive Pseudopodia Formation and Upregulates Plasminogen Activator Inhibitor-2 in Erlotinib-Resistant Non-Small Cell Lung Cancer Cells

Scientists identified the molecular biomarkers for HKB99 response in erlotinib-resistant HCC827ER cells and showed that HCC827ER cells displayed enhanced invasive pseudopodia structures as well as downregulated plasminogen activator inhibitor-2 . [Acta Pharmacol Sin] Abstract

Long Noncoding RNA MACC1-AS1 Promotes the Stemness of Nonsmall Cell Lung Cancer Cells through Promoting UPF1-Mediated Destabilization of LATS1/2

The authors showed that overexpression of MACC1-AS1 enhanced the stemness of non-small cell lung cancer cells, which was evident as the increased expression of cancer stem cell transcription factors, ALDH1 activity, and sphere-formation capacity, while knockdown of MACC1-AS1 decreased it. [Environ Toxicol] Abstract

Downregulation of LINC00665 Confers Decreased Cell Proliferation and Invasion via the miR-138-5p/E2F3 Signaling Pathway in NSCLC

LINC00665 expression was upregulated in non-small-cell lung cancer (NSCLC) lung tissues and cells. Downregulated LINC00665 could arrest A549 and H1299 cell proliferation and invasion in vitro. [Biomed Pharmacother] Abstract | Graphical Abstract

Performance Characteristics of a Real-Time Polymerase Chain Reaction Assay for the Detection of Epidermal Growth Factor Receptor (EGFR) Mutations in Plasma Samples of Non-Small Cell Lung Cancer (NSCLC) Patients

Scientists used K2-ethylenediaminetetraacetic acid plasma samples from non-small cell lung cancer patients and healthy donors, along with cell line DNA. [Mol Diagn Ther] Abstract

Citrus Lemon Essential Oil Nanoemulsion (CLEO-NE), a Safe Cell-Depended Apoptosis Inducer in Human A549 Lung Cancer Cells with Anti-Angiogenic Activity

30.2-nm CLEO-nanoemulsion droplets significantly increased Cas-3 in A549 cells and decreased angiogenesis in chick embryo chorioallantoic membrane. [J Microencapsul] Abstract

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Recent Advances in the Anti-Lung Cancer Activity of Biosynthesized Gold Nanoparticles

The authors focus on the advances in the anti-lung cancer activity of biosynthesized gold nanoparticles and its potential mechanisms. [J Cell Physiol] Abstract

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Novartis Announces FDA Approval of MET Inhibitor Tabrecta^™ for Metastatic Non-Small Cell Lung Cancer with METex14

Novartis announced that FDA approved Tabrecta^™, an oral MET inhibitor for adult patients with metastatic non-small cell lung cancer whose tumors have a mutation that leads to MET exon 14 skipping as detected by an FDA-approved test. [Novartis] Press Release

Relief Therapeutics Announces Filing of IND for Phase II/III Clinical Trial of Inhaled RLF-100 Targeting Early COVID-19 Lung Injury

Relief Therapeutics Holding AG announced that its US partner, NeuroRx Inc., has filed an investigational protocol with the FDA under the Coronavirus Treatment Acceleration Program to conduct a Phase II/III clinical trial assessing inhaled as a treatment for patients with non-acute lung injury caused by the SARS-CoV-2 virus. [Relief Therapeutics Holding AG] Press Release

Bionical Emas and Jazz Pharmaceuticals Enter into an Agreement for Expanded Access to Lurbinectedin in Relapsed Small Cell Lung Cancer in the United States

Bionical Emas and Jazz Pharmaceuticals have entered into an agreement to provide appropriate patients in the United States who have relapsed Small Cell Lung Cancer lurbinectedin via an Expanded Access Program. Lurbinectedin is an investigational drug under review by the FDA. [Bionical Emas] Press Release

Scientists Are Drowning in COVID-19 Papers. Can New Tools Keep Them Afloat?

Backed by large technology firms and the White House, a loose-knit army of data scientists, software developers, and journal publishers are racing to create digital collections holding thousands of freely available papers that could be useful to ending the pandemic, and scrambling to build data-mining and search tools that can help researchers quickly find the information they seek. [ScienceInsider] Editorial

House Democrats Include Research Dollars in Latest Pandemic Relief Package

For US scientists, the good news is that the $3 trillion spending bill unveiled contains billions of dollars in new research funding. The bad news is that the bill is only a marker for negotiations with Senate Republicans and the White House on what more the federal government should do to help the country deal with the devastating economic and health effects of the pandemic. [ScienceInsider] Editorial

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NEW Associate Professor – Cell Biology (Dana-Farber Cancer Institute)

Postdoctoral Scientist – Lung Cancer Clinical Research (Instituto de Investigación Hospital)

Principal Scientist – Respiratory Inflammation Research (Amgen Inc.)

Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

Branch Chief – Integrative Tumor Epidemiology (NIH National Cancer Institute)

PhD Studentship – Organoid Engineering in Lung Diseases (Helmholtz Zentrum München German Research Center for Environmental Health)

Laboratory Manager – Lung Diseases (Helmholtz Zentrum München)

Postdoctoral Fellow – SARS-CoV-2 Lung Infection (Boston University)

Research Fellow – Respiratory Viruses (Queen’s University Belfast)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Research Associate – Cystic Fibrosis (Michigan State University)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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