Pulmonary Cell News Volume 9.20 | May 28 2020

TOP STORY

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

COVID-19 autopsied lung studies identified focal disease and, congruent with culture data, SARS-CoV-2-infected ciliated and type 2 pneumocyte cells in airway and alveolar regions. [Cell] Abstract

(Ranked by impact factor of the journal)

miR-184 Mediates Hyperoxia-Induced Injury by Targeting Cell Death and Angiogenesis Signaling Pathways in the Developing Lung

The authors observed an increased expression of miR-184 in bronchopulmonary dysplasia (BPD) clinical specimens: tracheal aspirates, human neonatal lungs with BPD and in fetal human lung type II alveolar epithelial cells exposed to hyperoxia. [Eur Respir J] Abstract

Bioengineered Airway Epithelial Grafts with Mucociliary Function Based on Collagen IV- and Laminin-Containing Extracellular Matrix Scaffolds

Primary human airway epithelial cells adhered most readily to collagen IV. Biological, biomimetic and synthetic scaffolds were compared in terms of their extracellular matrix protein content and airway epithelial cell adherence. [Eur Respir J] Abstract

RNA Sequencing Analyses Reveal the Potential Mechanism of Pulmonary Injury Induced by Gallium Arsenide Particles in Human Bronchial Epithelioid Cells

Scientists employed physicochemical characterization of gallium arsenide obtained from a workplace, cytotoxicity analysis of damage induced by gallium arsenide in 16HBE cells. [Sci Rep] Full Article

Epithelial-Interleukin-1 Inhibits Collagen Formation by Airway Fibroblasts: Implications for Asthma

The release of IL-1α/β and IL-33 during airway epithelial differentiation was assessed over 20 days using air-liquid interface cultures. [Sci Rep] Full Article

LUNG CANCER

Defining COMMD4 as an Anti-Cancer Therapeutic Target and Prognostic Factor in Non-Small Cell Lung Cancer

Bioinformatic analysis and in vitro analysis of COMMD4 transcripts showed that COMMD4 levels were upregulated in non-small cell lung cancer and elevated COMMD4 was associated with poor prognosis in adenocarcinoma. [Br J Cancer] Full Article

Evaluation of the Activity of a Chemo-Ablative, Thermoresponsive Hydrogel in a Murine Xenograft Model of Lung Cancer

The thermoresponsive hydrogel demonstrated a dose-dependent cancer cell-specific toxicity in vitro and was retained in situ for at least 14 days in the xenograft model. [Br J Cancer] Abstract

CD133 Inhibition via Autophagic Degradation in Pemetrexed-Resistant Lung Cancer Cells by GMI, a Fungal Immunomodulatory Protein from Ganoderma Microsporum

GMI decreased the viability with short- and long-term effects and induced autophagy but not apoptosis in A549/A400 cells. [Br J Cancer] Abstract

RPL32 Promotes Lung Cancer Progression by Facilitating p53 Degradation

RPL32 silencing significantly inhibited the proliferation of lung cancer cells, with an observed p53 accumulation and cell cycle arrest. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-Small Cell Lung Cancer via ABCD-Member-4

Silencing DCLK1 inhibited non-small cell lung cancer cell primary and secondary spheroid formation, which were the prerequisite feature of tumor stem cells. [Mol Ther Oncolytics] Abstract | Graphical Abstract

Hypoxia-Induced GBE1 Expression Promotes Tumor Progression through Metabolic Reprogramming in Lung Adenocarcinoma

Hypoxia induced glycogen branching enzyme (GBE1) upregulation in lung adenocarcinoma cells. GBE1-knockdown A549 cells showed impaired cell proliferation, clone formation, cell migration and invasion, angiogenesis, tumor growth, and metastasis. [Signal Transduct Target Ther] Full Article

Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News.

Epithelial Cell Dysfunction, a Major Driver of Asthma Development

The authors focus on the role of airway epithelial barrier function in the susceptibility to develop asthma and novel insights in the modulation of epithelial cell dysfunction in asthma. [Allergy] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

Beyond Air Receives Approval from Health Canada to Study Nitric Oxide Generated and Delivered by the LungFit^™ in COVID-19 Patients

Beyond Air, Inc. announced that Health Canada approved the use of the LungFit™ system for a study in hospitalized patients diagnosed with COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [Beyond Air, Inc.] Press Release

Beyond Air Achieves Primary Endpoint in Pilot Bronchiolitis Study

Beyond Air, Inc. announced positive top-line results from its third pilot study in bronchiolitis patients that showed, on an intent-to-treat basis, 150 parts per million (ppm) NO is statistically significant compared to both the 85 ppm NO and control arms of the study. [Beyond Air, Inc.] Press Release

Alethia Biotherapeutics Announces Receipt of FDA Authorization to Begin Phase II Development for its EMT Inhibitor, AB-16B5

Alethia Biotherapeutics announced that the FDA has cleared its Phase II Investigational New Drug application for AB-16B5, a potent inhibitor of the epithelial to mesenchymal transition. This allows the company to initiate a multi-center trial of AB-16B5 in combination with docetaxel in previously treated subjects with metastatic non-small cell lung cancer. [Alethia Biotherapeutics] Press Release

What the Growing Rift Between the US and WHO Means for COVID-19 and Global Health

Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial

US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF

The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellow – Viral and Bacterial Lung Infections (Johns Hopkins University School of Medicine)

Postdoctoral Associate – Lung Cancer Research (Yale University)

Associate Professor – Cell Biology (Dana-Farber Cancer Institute)

Postdoctoral Scientist – Lung Cancer Clinical Research (Instituto de Investigación Hospital)

Principal Scientist – Respiratory Inflammation Research (Amgen Inc.)

Branch Chief – Integrative Tumor Epidemiology (NIH National Cancer Institute)

PhD Studentship – Organoid Engineering in Lung Diseases (Helmholtz Zentrum München German Research Center for Environmental Health)

Laboratory Manager – Lung Diseases (Helmholtz Zentrum München)

Postdoctoral Fellow – SARS-CoV-2 Lung Infection (Boston University)

Research Associate – Cystic Fibrosis (Michigan State University)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Pulmonary Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.