Pulmonary Cell News 9.20 May 28, 2020 | |
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TOP STORYSARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract COVID-19 autopsied lung studies identified focal disease and, congruent with culture data, SARS-CoV-2-infected ciliated and type 2 pneumocyte cells in airway and alveolar regions. [Cell] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors observed an increased expression of miR-184 in bronchopulmonary dysplasia (BPD) clinical specimens: tracheal aspirates, human neonatal lungs with BPD and in fetal human lung type II alveolar epithelial cells exposed to hyperoxia. [Eur Respir J] Abstract Primary human airway epithelial cells adhered most readily to collagen IV. Biological, biomimetic and synthetic scaffolds were compared in terms of their extracellular matrix protein content and airway epithelial cell adherence. [Eur Respir J] Abstract Scientists employed physicochemical characterization of gallium arsenide obtained from a workplace, cytotoxicity analysis of damage induced by gallium arsenide in 16HBE cells. [Sci Rep] Full Article Epithelial-Interleukin-1 Inhibits Collagen Formation by Airway Fibroblasts: Implications for Asthma The release of IL-1α/β and IL-33 during airway epithelial differentiation was assessed over 20 days using air-liquid interface cultures. [Sci Rep] Full Article LUNG CANCERBioinformatic analysis and in vitro analysis of COMMD4 transcripts showed that COMMD4 levels were upregulated in non-small cell lung cancer and elevated COMMD4 was associated with poor prognosis in adenocarcinoma. [Br J Cancer] Full Article The thermoresponsive hydrogel demonstrated a dose-dependent cancer cell-specific toxicity in vitro and was retained in situ for at least 14 days in the xenograft model. [Br J Cancer] Abstract GMI decreased the viability with short- and long-term effects and induced autophagy but not apoptosis in A549/A400 cells. [Br J Cancer] Abstract RPL32 Promotes Lung Cancer Progression by Facilitating p53 Degradation RPL32 silencing significantly inhibited the proliferation of lung cancer cells, with an observed p53 accumulation and cell cycle arrest. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract Silencing DCLK1 inhibited non-small cell lung cancer cell primary and secondary spheroid formation, which were the prerequisite feature of tumor stem cells. [Mol Ther Oncolytics] Abstract | Graphical Abstract Hypoxia induced glycogen branching enzyme (GBE1) upregulation in lung adenocarcinoma cells. GBE1-knockdown A549 cells showed impaired cell proliferation, clone formation, cell migration and invasion, angiogenesis, tumor growth, and metastasis. [Signal Transduct Target Ther] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSEpithelial Cell Dysfunction, a Major Driver of Asthma Development The authors focus on the role of airway epithelial barrier function in the susceptibility to develop asthma and novel insights in the modulation of epithelial cell dysfunction in asthma. [Allergy] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSBeyond Air, Inc. announced that Health Canada approved the use of the LungFitâ„¢ system for a study in hospitalized patients diagnosed with COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [Beyond Air, Inc.] Press Release Beyond Air Achieves Primary Endpoint in Pilot Bronchiolitis Study Beyond Air, Inc. announced positive top-line results from its third pilot study in bronchiolitis patients that showed, on an intent-to-treat basis, 150 parts per million (ppm) NO is statistically significant compared to both the 85 ppm NO and control arms of the study. [Beyond Air, Inc.] Press Release Alethia Biotherapeutics announced that the FDA has cleared its Phase II Investigational New Drug application for AB-16B5, a potent inhibitor of the epithelial to mesenchymal transition. This allows the company to initiate a multi-center trial of AB-16B5 in combination with docetaxel in previously treated subjects with metastatic non-small cell lung cancer. [Alethia Biotherapeutics] Press Release | |
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POLICY NEWSWhat the Growing Rift Between the US and WHO Means for COVID-19 and Global Health Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Associate – Lung Cancer Research (Yale University) Associate Professor – Cell Biology (Dana-Farber Cancer Institute) Postdoctoral Scientist – Lung Cancer Clinical Research (Instituto de Investigación Hospital) Principal Scientist – Respiratory Inflammation Research (Amgen Inc.) Branch Chief – Integrative Tumor Epidemiology (NIH National Cancer Institute) Laboratory Manager – Lung Diseases (Helmholtz Zentrum München) Postdoctoral Fellow – SARS-CoV-2 Lung Infection (Boston University) Research Associate – Cystic Fibrosis (Michigan State University) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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