| Vol. 5.24 – 06 July, 2020 |
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| Primary adult rat ventricular myocytes were studied for morphology and intracellular signaling. Cardiac myocyte-specific CIP4 gene deletion in mice attenuated pressure overload-induced pathological cardiac remodeling and heart failure. [Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed an intrinsic color sensing system utilizing a microgroove structural color methacrylated gelatin film, which allowed them to monitor the cardiac differentiation process of hiPSC-derived cardiac progenitor cells in real time. [ACS Nano] |
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| Induced pluripotent stem cells were generated and further differentiated to cardiomyocytes using standard methods from two well-characterized Tetralogy of Fallot patients and their healthy relatives serving as controls. [Scientific Reports] |
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| Investigators utilized human induced pluripotent stem cell-derived cardiomyocytes as a model to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2. [Cell Reports Medicine] |
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| In neonatal rat cardiomyocytes, overexpression of GJA1-20k attenuated Ang II-induced cardiomyocyte hypertrophy and caused elevated levels of gap junction coupling at the cell-cell borders. [Acta Pharmacologica Sinica] |
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| Scientists found no difference in the percentage of dying cells in immunodeficient dystrophic mouse muscles at the times after the irradiation dose that enhanced donor cell engraftment. [Scientific Reports] |
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| Differential expression analysis identified transcriptional profiles altered in the activated muscle stem/progenitor cells including genes associated with aging, obesity, diabetes, and impaired muscle regeneration, as well as long non-coding RNAs previously undescribed in human myogenic cells. [Skeletal Muscle] |
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| Trypsin was shown to evoke contraction of tracheal tissue via activation of PAR-2-TRPV4-ATP-cysLT axis indicating the potential disease relevance of this signaling pathway. [European Respiratory Journal] |
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| Abelson interactor 1 (Abi1) knockdown by shRNA reduced human airway smooth muscle cell migration, which was restored by Abi1 rescue. Abi1 localized at the tip of lamellipodia and its protrusion coordinated with F-actin at the leading cell edge of live cells. [Scientific Reports] |
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| Vascular smooth muscle cells (VSMCs) undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 and granulocyte-macrophage colony stimulating factor, leading to their secretion. [Apoptosis] |
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| The authors provide an overview of the beneficial adaptive responses to exercise and detail the molecular mechanisms involved. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach. [Nature Reviews Endocrinology] |
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| Sarepta Therapeutics, Inc. announced an agreement with Hansa Biopharma, the leader in immunomodulatory enzyme technology for rare Immunoglobulin G mediated diseases, for imlifidase. [Sarepta Therapeutics] |
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| In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease. [The Scientist] |
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| July 13 – July 16 Virtual |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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| University Hospital of Muenster – Muenster, Germany |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of California, Davis – Davis, California, United States |
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| Spanish National Center for Cardiovascular Research – Madrid, Spain |
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