| Vol. 11.27 – 16 July, 2020 |
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| Investigators demonstrated the interplay of extracellular space (ECS), ECM and glia in pathology, unraveling ECS features relevant for the α-synuclein propagation hypothesis and suggesting matrix manipulation as a disease-modifying strategy. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quantify microtubules dynamics in live xenograft tumor models. [Nature Communications] |
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| The authors showed that integrins play a key role during fly hematopoiesis in regulating cell signals that control the behavior of hematopoietic progenitors. Integrins can regulate hematopoiesis directly, via focal adhesion kinase signaling, and indirectly, by directing ECM assembly and/or maintenance. [Current Biology] |
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| Researchers revealed mitogen-activated protein kinase 7/matrix metallopeptidase 9 (MAPK7/MMP9) signaling as a driver for primary bone cancer metastasis. RNA interference knockdown of MAPK7 reduced proliferation, colony formation, migration, tumor growth, macrophage residency/polarisation and lung metastasis. [Oncogene] |
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| Scientists provided evidence that TGF-β disrupted the lineage commitment and promoted the accumulation of tumor-initiating cells in pre-neoplastic cells. [Scientific Reports] |
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| Researchers used a lentiviral chondroitinase ABC, capable of being secreted from mammalian cells, to examine the repercussions of chondroitin sulphate proteoglycans digestion upon Schwann cell behaviour in vitro. [Scientific Reports] |
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| Scientists provided relevant information on the future use of protein inclusion bodies in cow mammary gland and the role of matrix metalloproteinase-9 at dry-off. [Scientific Reports] |
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| Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils. [Journal of Biomedical Materials Research Part A] |
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| Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research. [Nature Reviews Cancer] |
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| Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences. [Science Insider] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing. [Nature News] |
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| The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently. [Nature News] |
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| August 27 – August 29 Virtual |
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| TU Dresden – Dresden, Germany |
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| Ludwig Boltzmann Gesellschaft GmbH – Vienna, Austria |
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| Helmholtz Zentrum München – Neuherberg, Germany |
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| Drexel University – Philadelphia, Pennsylvania, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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