Mammary Cell News Volume 12.28 | Jul 23 2020

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    2020-07-23 | MCN 12.28


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.28 – 23 July, 2020
    TOP STORY

    LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis

    Scientists showed that LEFTY1, a secreted inhibitor of NODAL/SMAD2 signaling, was produced by mammary progenitor cells and, concomitantly, suppressed SMAD2 and SMAD5 signaling to promote long-term proliferation of normal and malignant mammary epithelial cells.
    [Cell Stem Cell]

    AbstractGraphical Abstract

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    An Enhanced Chemopreventive Effect of Methyl Donor S-Adenosylmethionine in Combination with 25-Hydroxyvitamin D in Blocking Mammary Tumor Growth and Metastasis

    Researchers showed that both S-adenosylmethionine and 25-hydroxyvitamin D monotherapy reduced proliferation and clonogenic survival of a panel of breast cancer cell lines in vitro and inhibited tumor growth, lung metastasis, and breast tumor cell colonization to the skeleton in vivo. These effects were significantly more pronounced in the combination setting.
    [Bone Research]

    Full Article

    Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow

    Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
    [Oncogene]

    Abstract

    Development and Implementation of the SUM Breast Cancer Cell Line Functional Genomics Knowledge Base

    The SUM Breast Cancer Cell Line Knowledge Base provides information on the derivation of each cell line, protocols for the proper maintenance of the cells, and a series of data mining tools that allow rapid identification of the oncogene signatures for each line.
    [NPJ Breast Cancer]

    Full Article

    Immunostimulatory and Anti-Tumor Metronomic Cyclophosphamide Regimens Assessed in Primary Orthotopic and Metastatic Murine Breast Cancer

    Cyclophosphamide (CTX) increased expression of tumor cell PD-L1; however, when combined with concomitant PD-L1 antibody therapy none of the CTX regimens showed increased benefit.
    [NPJ Breast Cancer]

    Full Article

    NCAPG Confers Trastuzumab Resistance via Activating SRC/STAT3 Signaling Pathway in HER2-Positive Breast Cancer

    Researchers found that non-structural maintenance of chromosome condensin 1 complex subunit G expression was highly upregulated in trastuzumab-resistant HER2+ breast cancer.
    [Cell Death & Disease]

    Full Article

    Cancer Cells Grown in 3D under Fluid Flow Exhibit an Aggressive Phenotype and Reduced Responsiveness to the Anti-Cancer Treatment Doxorubicin

    Investigators developed an in vitro 3D model comprising a central high-density mass of breast cancer cells surrounded by collagen type-1 and they incorporated fluid flow and pressure.
    [Scientific Reports]

    Full Article

    Nephronectin Promotes Breast Cancer Brain Metastatic Colonization via Its Integrin-Binding Domains

    Scientists demonstrated a role for the extracellular matrix protein, nephronectin, in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells.
    [Scientific Reports]

    Full Article

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    The 5,6‐Epoxycholesterol Metabolic Pathway in Breast Cancer: Emergence of New Pharmacological Targets

    The authors present current knowledge of the 5,6‐epoxycholesterols (5,6‐EC) metabolic pathway in breast cancer, focusing on the 5,6‐EC metabolic enzymes, ChEH and HSD11B2, and on 5,6‐EC metabolite targets, LXRβ and GR.
    [British Journal of Pharmacology]

    Abstract

    Slug and E-Cadherin: Stealth Accomplices?

    This perspective article highlights Slug functions in mammary epithelial cells and breast cancer as a “non-epithelial-mesenchymal transition factor” in basal epithelial cells and stem cells with focus reports that demonstrate co-expression of Slug and E-cadherin.
    [frontiers in Molecular Biosciences]

    Full Article

    INDUSTRY AND POLICY NEWS

    Daiichi Sankyo and Gustave Roussy Enter Innovative Research Collaboration for DXd ADCs DS-1062 and Patritumab Deruxtecan

    Daiichi Sankyo Company, Ltd. and Gustave Roussy have announced a multi-year, multi-study research collaboration to enrich and further enable the development of DS-1062, and patritumab deruxtecan, two of Daiichi Sankyo’s lead DXd antibody drug conjugates, in lung and breast cancer.
    [Daiichi-Sankyo]

    Press Release

    Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

    For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Assistant Instructor – Breast Cancer

    University of Texas, Southwestern Medical Center – Dallas, Texas, United States

    Research Fellow – Molecular Pharmacology

    Mayo Clinic – Rochester, Minnesota, United States

    Assistant Scientists – Cell Cycle Regulation

    Georgetown University Medical Center – Washington, District of Columbia, United States

    Postdoctoral Associate – Cancer Bioengineering

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai Medical School – Los Angeles, California, United States

    > See All Jobs

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