| Vol. 5.28 – 10 August, 2020 |
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| The authors investigated how complement interacted with the platelet/neutrophil extracellular traps (NETS)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies and NETs/human aortic endothelial cell co-cultures. [Journal of Clinical Investigation] |
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| | Researchers profiled transcriptomes of blood vascular endothelial cells from peripheral lymph nodes and map phenotypes to the vasculature. [Nature Communications] |
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| QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation. [Nature Communications] |
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| Scientists positioned the ERAD-associated ubiquitin ligase MARCH6 as a determinant of angiogenic sprouting and barrier integrity through its ability to promote the degradation of the rate-limiting cholesterol biosynthetic enzyme squalene epoxidase. [Cell Reports] |
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| Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation. [Oncogene] |
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| Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia. [Experimental and Molecular Medicine] |
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| The authors evaluated the impact of apoptotic exosome-like vesicles on endothelial gene expression and function in the context of a pro-apoptotic stimulus. [Scientific Reports] |
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| Investigators showed that plasma polymerized nanoparticles, synthesized in reactive gas discharges, could bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production. [Scientific Reports] |
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| Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations. [Acta Pharmacologica Sinica] |
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| Placental villous explants of noncomplicated placentae and BeWo cells were subjected to hypoxia. The effect of placental hypoxic-conditioned medium on intraluminal-induced contraction and endothelial barrier integrity in chorionic arteries was investigated using pressure myography. [Hypertension Research] |
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| Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat. [NPJ Microgravity] |
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| Reports of widespread thromboses and disseminated intravascular coagulation in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. This perspective has critical implications for treatment. [Nature Reviews Rheumatology] |
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| Many different groups have modified autologous diabetic endothelial-colony-forming cells to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification. [Cells] |
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| Clovis Oncology, Inc. announced treatment of the first patient in the Phase II portion of the LIO-1 trial evaluating the combination of lucitanib, Clovis’ investigational angiogenesis inhibitor, including VEGFR1-3, and Opdivo®, Bristol Myers Squibb’s PD-1 inhibitor, for the treatment of gynecologic cancers. [Clovis Oncology, Inc.] |
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| Aerpio Pharmaceuticals, Inc. and the US Government operating through the Medical Technology Enterprise Consortium announced that an agreement has been reached to evaluate razuprotafib in a new randomized, investigational trial for the prevention and treatment of Acute Respiratory Distress Syndrome (ARDS) in adult patients with moderate to severe COVID-19. [Aerpio Pharmaceuticals, Inc.] |
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| September 7 – September 11, 2022 Virtual |
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| United Therapeutics – Silver Spring, Maryland, United States |
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| Technical University of Denmark – Lyngby, Denmark |
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| Albert Einstein College of Medicine – New York, New York, United States |
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| Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| Universitätsklinikum Bonn – Bonn, Germany |
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