Endothelial Cell News Volume 5.28 | August 10 2020

May 12, 2022

ENDOCN 5.28

Endothelial Cell News by STEMCELL Technologies

Vol. 5.28 – 10 August, 2020

TOP STORY

Complement and Tissue Factor-Enriched Neutrophil Extracellular Traps Are Key Drivers in COVID-19 Immunothrombosis

The authors investigated how complement interacted with the platelet/neutrophil extracellular traps (NETS)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies and NETs/human aortic endothelial cell co-cultures.
[Journal of Clinical Investigation]

Abstract
Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

A Molecular Map of Murine Lymph Node Blood Vascular Endothelium at Single Cell Resolution

Researchers profiled transcriptomes of blood vascular endothelial cells from peripheral lymph nodes and map phenotypes to the vasculature.
[Nature Communications]

Full Article

Targeting QKI-7 In Vivo Restores Endothelial Cell Function in Diabetes

QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation.
[Nature Communications]

Full Article

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

Scientists positioned the ERAD-associated ubiquitin ligase MARCH6 as a determinant of angiogenic sprouting and barrier integrity through its ability to promote the degradation of the rate-limiting cholesterol biosynthetic enzyme squalene epoxidase.
[Cell Reports]

Full Article Graphical Abstract

ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
[Oncogene]

Abstract

NF-κB-Dependent miR-31/155 Biogenesis Is Essential for TNF-α-Induced Impairment of Endothelial Progenitor Cell Function

Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]

Full Article

Apoptotic Exosome-Like Vesicles Regulate Endothelial Gene Expression, Inflammatory Signaling, and Function through the NF-κB Signaling Pathway

The authors evaluated the impact of apoptotic exosome-like vesicles on endothelial gene expression and function in the context of a pro-apoptotic stimulus.
[Scientific Reports]

Full Article

Plasma Polymerized Nanoparticles Effectively Deliver Dual siRNA and Drug Therapy In Vivo

Investigators showed that plasma polymerized nanoparticles, synthesized in reactive gas discharges, could bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production.
[Scientific Reports]

Full Article

Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]

Abstract

Placental Hypoxia-Induced Alterations in Vascular Function, Morphology, and Endothelial Barrier Integrity

Placental villous explants of noncomplicated placentae and BeWo cells were subjected to hypoxia. The effect of placental hypoxic-conditioned medium on intraluminal-induced contraction and endothelial barrier integrity in chorionic arteries was investigated using pressure myography.
[Hypertension Research]

Full Article

Interactome of miRNAs and Transcriptome of Human Umbilical Cord Endothelial Cells Exposed to Short-Term Simulated Microgravity

Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
[NPJ Microgravity]

Full Article

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REVIEWS

Emerging Evidence of a COVID-19 Thrombotic Syndrome Has Treatment Implications

Reports of widespread thromboses and disseminated intravascular coagulation in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. This perspective has critical implications for treatment.
[Nature Reviews Rheumatology]

Full Article

The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus

Many different groups have modified autologous diabetic endothelial-colony-forming cells to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification.
[Cells]

Full Article

INDUSTRY AND POLICY NEWS

Clovis Oncology Announces First Patient Enrolled in the Phase II Portion of the LIO-1 Trial Evaluating the Combination of Lucitanib and Opdivo in Gynecologic Cancers

Clovis Oncology, Inc. announced treatment of the first patient in the Phase II portion of the LIO-1 trial evaluating the combination of lucitanib, Clovis’ investigational angiogenesis inhibitor, including VEGFR1-3, and Opdivo^®, Bristol Myers Squibb’s PD-1 inhibitor, for the treatment of gynecologic cancers.
[Clovis Oncology, Inc.]

Press Release

Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib for the Prevention and Treatment of ARDS in Patients with Moderate to Severe COVID-19

Aerpio Pharmaceuticals, Inc. and the US Government operating through the Medical Technology Enterprise Consortium announced that an agreement has been reached to evaluate razuprotafib in a new randomized, investigational trial for the prevention and treatment of Acute Respiratory Distress Syndrome (ARDS) in adult patients with moderate to severe COVID-19.
[Aerpio Pharmaceuticals, Inc.]

Press Release

FEATURED EVENT

Complement and Tissue Factor-Enriched Neutrophil Extracellular Traps Are Key Drivers in COVID-19 Immunothrombosis

A Molecular Map of Murine Lymph Node Blood Vascular Endothelium at Single Cell Resolution

Targeting QKI-7 In Vivo Restores Endothelial Cell Function in Diabetes

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

NF-κB-Dependent miR-31/155 Biogenesis Is Essential for TNF-α-Induced Impairment of Endothelial Progenitor Cell Function

Apoptotic Exosome-Like Vesicles Regulate Endothelial Gene Expression, Inflammatory Signaling, and Function through the NF-κB Signaling Pathway

Plasma Polymerized Nanoparticles Effectively Deliver Dual siRNA and Drug Therapy In Vivo

Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Placental Hypoxia-Induced Alterations in Vascular Function, Morphology, and Endothelial Barrier Integrity

Interactome of miRNAs and Transcriptome of Human Umbilical Cord Endothelial Cells Exposed to Short-Term Simulated Microgravity

Emerging Evidence of a COVID-19 Thrombotic Syndrome Has Treatment Implications

The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus

Clovis Oncology Announces First Patient Enrolled in the Phase II Portion of the LIO-1 Trial Evaluating the Combination of Lucitanib and Opdivo in Gynecologic Cancers

Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib for the Prevention and Treatment of ARDS in Patients with Moderate to Severe COVID-19

Channels in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

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Intern – Regenerative Medicine in Pulmonary Hypertension

Postdoctoral Scholarship – Endothelial Cells in Diabetic Retinopathy

Postdoctoral Position – Cardiovascular and Cardiomyopathy Research

Senior Postdoctoral Research Fellow – Molecular Mechanisms of Viral Pathogenesis

Professor – Endothelial Cell Biology

> See All Jobs