 | | Vol. 15.31 – 19 August, 2020 |
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| Researchers generated human islet-like organoids from iPSCs and showed that non-canonical WNT4 signaling drove the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Human PSCs were subject to directed differentiation through a paraxial mesoderm progenitor state that generated brown adipocytes (BAs) at high efficiency. Molecular analysis identified potential regulatory networks for BA development, giving insight into development along this lineage.
[Cell Stem Cell] |
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| Researchers derived PSCs from distinct mouse strains under naive conditions and showed that lines from distinct genetic backgrounds have divergent differentiation capacity, confirming a major role for genetics in PSC phenotypic variability.
[Cell Stem Cell] |
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| Investigators present dynamic full-field optical coherence tomography as a technique to noninvasively image living human iPSC-derived retinal organoids.
[Light-Science & Applications] |
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| A quantitative proteomic comparison between metaphase-arrested cell lysates and chromosome-sorted samples revealed a cohort of proteins that were significantly enriched on mitotic ESC chromosomes.
[Nature Communications] |
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| Scientists developed a microfluidic chip formed by Hutchinson-Gilford Progeria Syndrome-Smooth muscle cells generated from iPSCs, to study their vulnerability to flow shear stress.
[Nature Communications] |
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| Brain organoids derived from iPSCs of patients are a powerful avenue to investigate the pathophysiological processes. Scientists generated iPSC-derived cerebral organoids from monozygotic twins discordant for psychosis.
[Molecular Psychiatry] |
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| Investigators established an in vitro model of hydatidiform mole using patient-specific iPSCs derived trophoblasts harboring NLRP7 mutations.
[Cell Death & Disease] |
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| Researchers focused on using Wnt inhibitors to study the differentiation of human iPSC-cardiac progenitor cells under 2D or 3D culture conditions.
[Scientific Reports] |
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| During 3D organoid formation, the origin of iPSCs affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences] |
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| The authors examine the advantages and limitations of iPSC technology, summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular and central nervous system, and describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies.
[British Journal of Pharmacology] |
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| Scientists review the fundamental links between the stem cell-specific HR process and DNA damage response as well as the different strategies employed by ESCs to maintain genomic integrity.
[Experimental and Molecular Medicine] |
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| The authors summarize the state-of-the-art understanding of mesoderm development and in vitro modeling of mesoderm development using PSCs. They also discuss future perspectives on the use of PSCs to generate skeletal tissues for basic research and clinical applications.
[Experimental and Molecular Medicine] |
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| For patients who’ve run out of other options, experimental, unproven therapies like stem cell treatments offer new hope. But how do you sort the scientifically legitimate from the dangerous?
[STAT News] |
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| July 8 – July 10, 2021
Boston, Massachusetts, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of Miami Health System – Miami, Florida, United States |
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| | Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany |
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| | The Stem Cell Unit at the University Medical Center Göttingen – Göttingen, Germany |
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