| Vol. 11.39 – 6 October, 2020 |
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| To identify determinants of bone marrow failure, researchers performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report the design and in vivo performance of systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA, for the silencing of genes in bone-marrow endothelial cells. [Nature Biomedical Engineering] |
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| The authors showed that, during mouse acute liver injury, the density of megakaryocyte in the bone marrow increases following an increase in circulating platelet-derived microparticles, but without thrombopoietin upregulation. [Nature Communications] |
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| Scientists describe the circuitry of a transactivation system responsible for oncogenic self-renewal. MLL recruited RNA polymerase II to unmethylated CpG-rich promoters by its CXXC domain and activated transcription by transcriptional regulators, including the AF4 family/ENL family/P-TEFb complex, DOT1L, and p300/CBP histone acetyl transferases. [Cell Reports] |
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| Investigators introduced a low-input tagmentation-based Hi-C (tagHi-C) method to capture the chromatin structures of hundreds of cells. Using tagHi-C, they were able to map the spatiotemporal dynamics of chromatin structure in ten primary hematopoietic stem, progenitor, and differentiated cell populations from mouse bone marrow. [Cell Reports] |
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| The authors expanded RASGRP1 expression surveys in pediatric T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells. [Oncogene] |
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| Scientists report that partial disruption of Separase distinctly alters the functional characteristics of hematopoietic stem/progenitor cells. [Stem Cells] |
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| Researchers report that the proportions of Lin-CD34+38– hematopoietic multipotent cells and of Lin-CD34+38+ hematopoietic progenitors cells were highly variable between individuals but stable over long periods of time, in both healthy individuals and sickle cell disease patients. [Cells] |
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| Using a MLL-AF9 knock-in mouse model, researchers discovered that consumption of a high-fat diet accelerates the risk of developing acute myeloid leukemia. [Scientific Reports] |
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| Investigators made an attempt to find out the osteoblastic niche related alterations in the myelodysplastic bone marrow through mainly flow cytometric and fluorescent microscopic studies. [Molecular and Cellular Biology] |
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| Scientists performed a targeted CRISPR-Cas9-based sgRNA screen to identify candidate genes that counteract the decreased repopulating capacity of hematopoietic stem and progenitor cells during gene therapy. [Cells] |
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| Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells. [Cancer Research] |
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| Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints. [Gamida Cell Ltd.] |
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| bluebird bio, Inc. announced that the European Medicines Agency accepted the company’s MAA for its investigational elivaldogene autotemcel gene therapy for the treatment of patients with CALD. [bluebird bio, Inc.] |
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| January 9 – January 12, 2021 Lake Buena Vista, Florida, United States |
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| Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Princeton University – Princeton, New Jersey, United States |
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| St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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