| Vol. 12.39 – 8 October, 2020 |
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| Researchers devised a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the fusion oncogenes specifically in cancer cells. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators combined the analysis of placenta epigenomic data with newly generated DNA methylation data obtained from 568 pregnant women, the largest cohort to date, either actively smoking during their pregnancy or formerly exposed to tobacco smoking. [BMC Medicine] |
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| Researchers created human induced pluripotent stem cells (hiPSCs) from different MSC sources to evaluate the capacity of MSC-derived iPSCs to differentiate into any cell type of the human body and to serve as an alternative source for iPSC generation. [Journal of Materials Chemistry B] |
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| Scientists assessed T cell reconstitution in patients transplanted with UM171-expanded cord blood (CB) grafts and retrospectively compared it to that of patients receiving unmanipulated CB transplants. [Biology of Blood and Marrow Transplantation] |
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| Investigators developed an injectable and mechanically strong calcium phosphate bone cement‐chitosan paste containing graphene oxide and investigated the inhibition of Staphylococcus aureus infection and the promotion of human umbilical cord MSCs for bone regeneration. [Journal of Tissue Engineering and Regenerative Medicine] |
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| Researchers systematically illuminated the spatio-temporal biofunction and mechanism of dual-fluorescence expressing placenta-derived MSCs on enterocutaneous fistula mice. [Stem Cell Reviews and Reports] |
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| Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function. [Brain Research Bulletin] |
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| The authors investigated the therapeutic effects of allogeneic platelet gel prepared from umbilical cord blood in a group of children diagnosed with dystrophic epidermolysis bullosa eligible for surgical correction of pseudosyndactyly in the hand. [Wound Repair and Regeneration] |
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| Investigators highlight the contributions of large animal models to the development and fine-tuning of hematopoietic cell transplant and additional cellular therapies to improve organ transplantation outcomes. [Biology of Blood and Marrow Transplantation] |
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| Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints. [Gamida Cell Ltd.] |
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| Affimed N.V. announced that the first patient was successfully dosed with allogeneic cord blood-derived natural killer cells preloaded with AFM13 and has moved on to the AFM13 monotherapy phase of the treatment cycle. This therapy was developed through a research collaboration with The University of Texas MD Anderson Cancer Center. [Affimed N.V.] |
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| Cynata Therapeutics has produced trial results confirming the initial success of its Cymerus MSCs in restoring cardiac function following a heart attack. [The West Australian] |
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| January 25 – January 27, 2021 Virtual |
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| The University of Chicago – Chicago, Illinois, United States |
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| University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| University of Miami – Miami, Florida, United States |
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| Purdue University – West Lafayette, Indiana, United States |
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