| Vol. 12.43 – 13 November, 2020 |
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| Scientists provide evidence that CRELD1, a pivotal factor for heart development, was an important gatekeeper of immune system homeostasis. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Rig-I or Mda5 deficiency reduced hematopoietic stem and progenitor cell numbers by inhibiting inflammatory signals that were in turn enhanced in Lgp2 deficient embryos. [Immunity] |
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| Natural killer (NK) cells have the potential to augment checkpoint inhibition therapies, such as PD-L1/PD-1 blockade, because NK cells mediate both direct tumor lysis and T cell activation and recruitment. [Science Translational Medicine] |
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| Intravenous oligodendrocyte-derived extracellular vesicles injection reduced disease pathophysiology in a myelin Ag–dependent manner, both prophylactically and therapeutically, in several experimental autoimmune encephalomyelitis models. [Science Translational Medicine] |
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| Scientists report that limiting glutamine metabolism in cancer cells bolstered the effectiveness of anti-programmed death ligand-1 antibody. [Molecular Cell] |
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| Researchers used skin-relevant, fluorescently-labeled bacterial, helminth or fungal pathogens to track and characterize the antigen-presenting cell populations that drove helper T responses in vivo. [Nature Communications] |
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| Blood eosinophils were increased in surviving patients with acute respiratory distress syndrome independent of corticosteroid usage. The homeostatic eosinophils in mice lung parenchyma, originating from the bone marrow, were predominantly CD101−. [European Respiratory Journal] |
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| Scientists showed that polymerase 1 and transcript release factor (PTRF) triggered a cytoplasmic phospholipase A2-mediated phospholipid remodeling pathway that promotes glioblastoma tumor proliferation and suppressed tumor immune responses. [Neuro-Oncology] |
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| ZMYND8 knockout (KO) in breast cancer cells promoted infiltration of CD4+ and CD8+ T cells leading to tumor inhibition in syngeneic mouse models, which was significantly attenuated by treatment of anti-CD4/CD8 depleting antibodies or anti-IFNAR1 antibody and in immunodeficient Rag1 KO mice. [Cancer Research] |
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| Scientists demonstrated that CCR1 expression was an independent prognostic indicator in newly diagnosed multiple myeloma patients. [Haematologica] |
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| Investigators created a gene expression compendium across 24 distinct human and murine lung and lymph node mononuclear phagocytes (MPs), along with human blood and murine spleen MPs, to serve as validation datasets. [Cell Reports] |
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| The authors focus on new findings that clarify the roles specific epigenetic regulators play in T cell-mediated acute graft-versus-host-disease development and discuss how their modulation could disrupt that process to beneficial effects. [Haematologica] |
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| Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Scientists summarize the role of neutrophils in liver diseases. [Cellular & Molecular Immunology] |
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| XNK Therapeutics AB announced it has received Orphan Drug Designation from the FDA for its leading investigational drug candidate in the treatment of multiple myeloma. [XNK Therapeutics AB] |
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| March 22 – March 24, 2021 Virtual |
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| University of Florida – Jacksonville, Florida, United States |
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| Queen’s University – Kingston, Ontario, Canada |
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| MRC Laboratory of Molecular Biology – Cambridge, England, United Kingdom |
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| Genentech, Inc. – South San Francisco, California, United States |
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| Terasaki Research Institute – Los Angeles, California, United States |
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