| Vol. 9.46 – 26 November, 2020 |
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| Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5+ basal cells. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived alveolar epithelial type 2 cells infected with SARS-CoV-2 at air-liquid interface. [Molecular Cell] |
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| Investigators compared two popular mixed fruit flavored electronic cigarette-liquids with and without nicotine aerosolized at 40 W with respect to particle number concentrations, chemical composition, and response on physiologically relevant human bronchial and alveolar lung mucosa models cultured at the air–liquid interface. [Scientific Reports] |
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| To overcome the scarcity of primary human alveolar epithelial cells for lung research, and the limitations of current cell lines to recapitulate the phenotype, functional and molecular characteristics of the healthy human alveolar epithelium, the authors developed a new method to immortalize primary human alveolar epithelial lung cells using a non-viral vector to transfect the telomerase catalytic subunit and the simian virus 40 large-tumor antigen. [Scientific Reports] |
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| Metastasis-derived cell lines in vitro and metastases analyzed ex vivo from an autochthonous lung cancer mouse model had lower mitochondrial membrane potential and reduced mitochondrial functionality than non-metastatic primary tumors. [Cancer Research] |
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| The authors report that glutamate transporters, in particular SLC1A1, were tightly intertwined with cystine uptake and glutathione biosynthesis in lung cancer cells. [Cancer Research] |
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| Investigators showed that the level of the amino acid serine in the cytosol affects the migratory properties of lung adenocarcinoma cells. [Cell Death & Disease] |
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| Scientists showed that upregulation promoting LUAD-associated transcript-1 (UPLA1) was highly expressed and regulated important biological functions in lung adenocarcinoma. In vitro experiments revealed that UPLA1 promoted the migration, invasion, and proliferation abilities, and was related to cell cycle arrest, in lung adenocarcinoma cells. [Cell Death & Disease] |
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| Researchers investigated the role of glutathione S‑transferase ω 1 (GSTO1) in non‑small cell lung cancer and determined the potential molecular mechanism. GSTO1 expression levels in A549 cells were knocked down using short hairpin RNA and GSTO1 overexpression in H2122 cells was achieved using cDNA constructs. [Molecular Medicine Reports] |
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| Critical signaling pathways related to pulmonary fibrosis (PF) were reviewed to present updates on the molecular mechanisms of PF. [Molecular Biology Reports] |
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| Novartis announced that it entered into an exclusive worldwide license and collaboration agreement with Mesoblast to develop, commercialize and manufacture remestemcel-L for the treatment of acute respiratory distress syndrome, including that associated with COVID-19. [Novartis AG] |
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| Matinas BioPharma Holdings, Inc. announced that it has been awarded up to $3.75 million from the Cystic Fibrosis Foundation. [Matinas BioPharma Holdings, Inc.] |
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| April 11 – April 13, 2021 San Diego, California, United States |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Max Planck Institute for Heart and Lung Research – Bad Nauheim, Germany |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| University of Saskatchewan – Saskatoon, Saskatchewan, Canada |
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