Pulmonary Cell News Volume 9.46 | Nov 26 2020

May 12, 2022

2020-26-11 | PULCN 9.46

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.46 – 26 November, 2020

TOP STORY

Progenitor Identification and SARS-CoV-2 Infection in Human Distal Lung Organoids

Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5⁺ basal cells.
[Nature]

Abstract

Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Actionable
Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

The authors performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived alveolar epithelial type 2 cells infected with SARS-CoV-2 at air-liquid interface.
[Molecular Cell]

Abstract Graphical Abstract

Addressing
the Challenges of E-Cigarette Safety Profiling by Assessment of Pulmonary Toxicological Response in Bronchial and Alveolar Mucosa Models

Investigators compared two popular mixed fruit flavored electronic cigarette-liquids with and without nicotine aerosolized at 40 W with respect to particle number concentrations, chemical composition, and response on physiologically relevant human bronchial and alveolar lung mucosa models cultured at the air–liquid interface.
[Scientific Reports]

Full Article

Immortalization
of Primary Human Alveolar Epithelial Lung Cells Using a Non-Viral Vector to Study Respiratory Bioreactivity In Vitro

To overcome the scarcity of primary human alveolar epithelial cells for lung research, and the limitations of current cell lines to recapitulate the phenotype, functional and molecular characteristics of the healthy human alveolar epithelium, the authors developed a new method to immortalize primary human alveolar epithelial lung cells using a non-viral vector to transfect the telomerase catalytic subunit and the simian virus 40 large-tumor antigen.
[Scientific Reports]

Full Article

LUNG CANCER

Altered
Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability

Metastasis-derived cell lines in vitro and metastases analyzed ex vivo from an autochthonous lung cancer mouse model had lower mitochondrial membrane potential and reduced mitochondrial functionality than non-metastatic primary tumors.
[Cancer Research]

Abstract

Dysregulated
Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer

The authors report that glutamate transporters, in particular SLC1A1, were tightly intertwined with cystine uptake and glutathione biosynthesis in lung cancer cells.
[Cancer Research]

Abstract

Cytosolic
Serine Hydroxymethyltransferase Controls Lung Adenocarcinoma Cells Migratory Ability by Modulating AMP Kinase Activity

Investigators showed that the level of the amino acid serine in the cytosol affects the migratory properties of lung adenocarcinoma cells.
[Cell Death & Disease]

Full Article

Novel lncRNA UPLA1 Mediates Tumorigenesis and Prognosis in Lung Adenocarcinoma

Scientists showed that upregulation promoting LUAD-associated transcript-1 (UPLA1) was highly expressed and regulated important biological functions in lung adenocarcinoma. In vitro experiments revealed that UPLA1 promoted the migration, invasion, and proliferation abilities, and was related to cell cycle arrest, in lung adenocarcinoma cells.
[Cell Death & Disease]

Full Article

Glutathione
S‑Transferase ω 1 Promotes the Proliferation, Migration and Invasion, and Inhibits the Apoptosis of Non‑Small Cell Lung Cancer Cells, via the JAK/STAT3 Signaling Pathway

Researchers investigated the role of glutathione S‑transferase ω 1 (GSTO1) in non‑small cell lung cancer and determined the potential molecular mechanism. GSTO1 expression levels in A549 cells were knocked down using short hairpin RNA and GSTO1 overexpression in H2122 cells was achieved using cDNA constructs.
[Molecular Medicine Reports]

Abstract Full Article

Tools and products for your COVID-19 research.

REVIEWS

Latest
Progress on the Molecular Mechanisms of Idiopathic Pulmonary Fibrosis

Critical signaling pathways related to pulmonary fibrosis (PF) were reviewed to present updates on the molecular mechanisms of PF.
[Molecular Biology Reports]

Abstract

INDUSTRY AND POLICY NEWS

Novartis Secures Exclusive Rights for Potential Acute Respiratory Distress Syndrome Cell Therapy

Novartis announced that it entered into an exclusive worldwide license and collaboration agreement with Mesoblast to develop, commercialize and manufacture remestemcel-L for the treatment of acute respiratory distress syndrome, including that associated with COVID-19.
[Novartis AG]

Press Release

Matinas BioPharma Awarded up to $3.75 Million from the Cystic Fibrosis Foundation to Support Development of Oral Amikacin (MAT2501) for the Treatment of NTM Infections in Cystic Fibrosis Patients

Matinas BioPharma Holdings, Inc. announced that it has been awarded up to $3.75 million from the Cystic Fibrosis Foundation.
[Matinas BioPharma Holdings, Inc.]

Press Release

FEATURED EVENT

Progenitor Identification and SARS-CoV-2 Infection in Human Distal Lung Organoids

Actionable
Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Addressing
the Challenges of E-Cigarette Safety Profiling by Assessment of Pulmonary Toxicological Response in Bronchial and Alveolar Mucosa Models

Immortalization
of Primary Human Alveolar Epithelial Lung Cells Using a Non-Viral Vector to Study Respiratory Bioreactivity In Vitro

Altered
Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability

Dysregulated
Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer

Cytosolic
Serine Hydroxymethyltransferase Controls Lung Adenocarcinoma Cells Migratory Ability by Modulating AMP Kinase Activity

Novel lncRNA UPLA1 Mediates Tumorigenesis and Prognosis in Lung Adenocarcinoma

Glutathione
S‑Transferase ω 1 Promotes the Proliferation, Migration and Invasion, and Inhibits the Apoptosis of Non‑Small Cell Lung Cancer Cells, via the JAK/STAT3 Signaling Pathway

Latest
Progress on the Molecular Mechanisms of Idiopathic Pulmonary Fibrosis

Novartis Secures Exclusive Rights for Potential Acute Respiratory Distress Syndrome Cell Therapy

Matinas BioPharma Awarded up to $3.75 Million from the Cystic Fibrosis Foundation to Support Development of Oral Amikacin (MAT2501) for the Treatment of NTM Infections in Cystic Fibrosis Patients

Cell Symposia: 20 Years of the Human Genome: From Sequence to Substance

> See All Events

Postdoctoral Fellow Position – Host-Pathogen Interactions

Postdoctoral
Fellowship – Pro-Metastatic Tumor Microenvironment

Postdoctoral Research Position and PhD Position – Cardiovascular and Lung Diseases

Faculty
Position – Oncology & Lung Cancer

Assistant
Professor – Respirologist

> See All Jobs