| Vol. 12.45 – 27 November, 2020 |
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| Scientists found that MEK1/2 inhibition induced stem cell–like memory T cells that had naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators report the development of genetically engineered outer membrane vesicles whose surface has been modified by insertion of the ectodomain of programmed death 1. [ACS Nano] |
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| The authors identified a new phase of functional compensation following acute liver injury that occurs prior to cellular proliferation. [Nature Communications] |
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| CD34‐CD42b platelet‐targeting bispecific antibodies were designed to simultaneously recognize HSCs and platelets. After inhalation delivery, PT‐BsAbs reached the lungs and conjoined HSCs and platelets. [Advanced Science] |
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| Researchers identified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity. Peli1 ablation profoundly promotes tumor rejection, associated with increased tumor‐infiltrating CD4 and CD8 T cells. [EMBO Journal] |
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| Scientists studied the effects of high-dose per fraction radiotherapy with and without anti-Gr-1 using syngeneic murine allograft prostate cancer models. The dynamic change of immune populations, including tumor-infiltrating lymphocytes, T-regulatory cells, and myeloid-derived suppressive cells was evaluated using flow cytometry and immunohistochemistry. [Clinical Cancer Research] |
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| Investigators report that hyperactive DCs have an enhanced ability to migrate to draining lymph nodes and stimulate potent cytotoxic T lymphocyte responses. [Cell Reports] |
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| Deficiency of TRIM60 in macrophages led to enhanced MAPK and NF-κB activation, accompanied by elevated levels of proinflammatory cytokines but not IFN-I. [Cellular & Molecular Immunology] |
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| The authors showed that genetic disruption of interleukin-17 receptor D (Il17rd) led to the increased formation of spontaneous tumors in multiple tissues of aging mice. Loss of IL-17RD also promoted tumor development in a model of colitis-associated colorectal cancer, associated with an exacerbated inflammatory response. [Oncogene] |
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| Scientists demonstrated that a lead cyclic dinucleotide carrier formulation can enhance stimulator of interferon gene activation in vivo in a model of intratumoral immunotherapy. [Advanced Healthcare Materials] |
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| To increase the efficacy of AT1413 as a therapeutic antibody, researchers generated two different formats of bispecific T-cell engaging antibodies to both CD43s and CD3ε. [Cancer Immunology Immunotherapy] |
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| Nanoparticles were assessed in vivo for retention, bio-distribution and immunoreactivity. Cyclodextrin molecules via polyethylene glycol induced a temporary blood monocyte response and was cleared effectively from the body through the urine system in mice. [Journal of Cellular and Molecular Medicine] |
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| Scientists review the recent findings in post-translational modifications in macrophages and T cells and speculate whether they could be of use in the effort to develop therapeutics for immune-related diseases. [Immunity] |
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| The authors summarize the discovery and development of Tregs, and discuss the outstanding challenges of Treg cell therapy and its future prospects for routine use in liver transplantation. [Liver Transplantation] |
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| The L’Oréal-UNESCO For Women in Science Middle East Regional Young Talents Program, in partnership with Khalifa University of Science and Technology, awarded six winners in the Post-doctorate Researchers and PhD Students categories where Dr. Lama AlAbdi (KSA), Dr. Isra Marei (Qatar), and Dr. Maryam Tariq Khaleel Alhashmi (UAE) each received EUR20,000 in the Post-doctorate Researchers category. [L’Oréal-UNESCO (Business Today)] |
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| January 11 – January 13, 2021 Virtual |
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| Rubius Therapeutics – Cambridge, Massachusetts, United States |
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| University of Dundee – Dundee, Scotland, United Kingdom |
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| Genentech, Inc. – South San Francisco, California, United States |
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| Queen’s University – Kingston, Ontario, Canada |
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| Terasaki Research Institute – Los Angeles, California, United States |
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