| Vol. 9.02 – 19 January, 2021 |
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| Scientists report a role of interleukin-10-producing type 2 innate lymphoid cells in modulating grass-pollen allergy. They demonstrated that KLRG1+ but not KLRG1– ILC2 produced IL-10 upon activation with IL-33 and retinoic acid. [Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed the molecular determinants of monocytic and macrophagic commitment by profiling the EGR1 transcription factor. EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. [Science Advances] |
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| Investigators showed improved differentiation efficiency of T-cells from induced PSCs (iPSCs) derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials. [Nature Communications] |
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| Scientists explored the role of the immune cell-secreted serine protease, granzyme B, in pemphigoid disease pathogenesis using three independent murine models. In all models, granzyme B knockout or topical pharmacological inhibition significantly reduced total blistering area compared to controls. [Nature Communications] |
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| Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients. [Cell Reports] |
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| The authors focused on the important role of macrophage polarization in cecal ligation puncture-mediated acute lung injury and determined the ability of saquinavir to maintain M2 over M1 phenotype partially through the inhibition of matrix metalloproteinase-9. [Cell Death & Disease] |
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| Scientists investigated the relationship between the expression levels of hsa_circ_0007456 in HCC and the susceptibility of NK cells, and found that the expression levels of hsa_circ_0007456 in HCC cell lines significantly influenced their susceptibility to NK cells. [Cell Death & Disease] |
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| Investigators showed that hemibodies addressing CD38 and SLAMF7 recruited T cells for the exquisite elimination of dual antigen positive multiple myeloma cells while leaving single antigen positive bystanders unharmed. [Communications Biology] |
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| To characterize coordinate changes at different levels of chromatin architecture, researchers analyzed chromatin accessibility, chromosome conformation and gene expression in activated human T cells. [Scientific Reports] |
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| Scientists discuss the mechanisms by which the signaling of ERBB family members affects not only autonomous cancer hallmarks, such as uncontrolled cell proliferation, but also antitumor immune responses in the tumor microenvironment and the potential application of immune-genome precision medicine into immunotherapy. [Nature Reviews Cancer] |
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| The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems. [Nature Reviews Immunology] |
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| Scientists present an overview of nanomaterials that have been used to overcome clinical barriers to T-cell-based immunotherapies and provide their outlook of this emerging field at the interface of cancer immunotherapy and nanomaterial design. [Nature Nanotechnology] |
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| Boehringer Ingelheim and Enara Bio, announced that they have entered into a strategic collaboration and licensing agreement to research and develop novel targeted cancer immunotherapies, leveraging Enara Bio’s Dark Antigen™ discovery platform. [Boehringer Ingelheim (BusinessWire, Inc)] |
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| February 3 – 23, 2021 Virtual |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| The Francis Crick Institute – London, England, United Kingdom |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| Systimmune, Inc. – Redmond, Washington, United States |
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| University of Florida – Gainesville, Florida, United States |
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