| Vol. 15.02 – 20 January, 2021 |
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| A computational approach for unbiased identification of core biological traits of single cells and bulk tumors uncovered four tumor cell states and glioblastoma subtypes distributed along neurodevelopmental and metabolic axes, classified as proliferative/progenitor, neuronal, mitochondrial, and glycolytic/plurimetabolic. [Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The links among altered O-linked β-N-acetylglucosaminylation (O-GlcNAcylation), β-amyloid accumulation, and necroptosis are unclear. The authors found that O-GlcNAcylation played a protective role in Alzheimer’s disease by inhibiting necroptosis. [Science Advances] |
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| Researchers showed that FMRpolyG interacted with pathogenic CGG repeat-derived RNA G-quadruplexes, propagated cell to cell, and induced neuronal dysfunction. [Science Advances] |
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| The authors report the significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration. [Nature Communications] |
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| Researchers investigated the role of glucocorticoids in mitophagy inhibition and subsequent synaptic defects in hippocampal neurons, SH-SY5Y cells, and ICR mice. [Nature Communications] |
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| Scientists identified a subset of inhibitory interneurons in the spinal dorsal horn (SDH) operated by adeno-associated viral vectors incorporating a neuropeptide Y promoter (AAV-NpyP+) and showed that specific ablation or silencing of AAV-NpyP+ SDH interneurons converted touch-sensing Aβ fiber-derived signals to morphine-resistant pain-like behavioral responses. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators evaluated the mechanistic contributions of protein inhibitor of activated STAT-1 (PIAS1) in Huntington’s disease (HD) mice and HD patient-derived induced pluripotent stem cells and found a link between PIAS1 and DNA damage repair pathways. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells. [eLife] |
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| Investigators identified that the transcription factor 4-mediated cell death was essential for generating an appropriate number of oligodendrocyte progenitor cells and thereby oligodendrocytes in the olfactory bulb. [Cell Death & Disease] |
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| Researchers induced selective mitochondrial DNA damage in neuronal axons using microfluidic chambers that allowed for the spatial and fluidic isolation of neuronal cell bodies from the axons. [Cell Death & Disease] |
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| The authors report that growth differentiation factor 15 (GDF15) promoted the glioma stem cell (GSC)-like phenotype in GSC-like cells through the activation of leukemia inhibitor factor (LIF)–STAT3 signaling. [Cell Death Discovery] |
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| Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation. [Cell Death Discovery] |
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| Investigators review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity. [Experimental and Molecular Medicine] |
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| Neurogene, Inc. and University of Edinburgh announced a collaboration to advance development of multiple platform approaches designed to enable next generation gene therapies. The collaboration provides comprehensive research capabilities to Neurogene, enabling the company and the university to expedite a multiple platform approach to improve upon existing gene therapy technologies. [Neurogene, Inc.] |
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| MediciNova, Inc announced that it has received a Notice of Allowance from the Japan Patent Office for a pending patent application which covers the combination of ibudilast and riluzole for the treatment of ALS. [MediciNova, Inc] |
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| North Carolina State University – Raleigh, North Carolina, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Kentucky – Lexington, Kentucky, United States |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| Novo Nordisk – Copenhagen, Denmark |
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