| Vol. 6.04 – 1 February, 2021 |
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| Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage. [Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Conduction properties and cytoskeleton structure of human induced pluripotent stem cell-derived cardiomyocytes obtained from a healthy donor under cyclophosphamide were evaluated. [Scientific Reports] |
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| Researchers developed a disease model using iPSC-derived cardiomyocytes (iPSC-CMs) from a healthy individual and two Myotonic Dystrophy type 1 patients with different CTG repeats lengths and clinical history. [Scientific Reports] |
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| Cardiomyocyte viability, bioenergetic response and calcium transients were determined in the presence of oxidized phosphatidylcholines (OxPCs). Fragmented OxPCs resulted in a decrease in cell viability with POVPC and PONPC having the most potent cardiotoxic effect in both a concentration and time dependent manner. [American Journal of Physiology-Heart and Circulatory Physiology] |
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| Researchers revealed that the expressions of ZFAS1 and Sp1 were significantly reduced in LPS-treated H9C2 cells and primary cultured mouse neonatal cardiomyocytes. The downregulation of ZFAS1 and Sp1 were also found in cardiomyocytes obtained from LPS-challenged mice. [Cytokine] |
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| Scientists report an approach for the fabrication of shape-changing bilayered scaffolds, which allowed the growth of aligned skeletal muscle cells, using a combination of 3D printing of hyaluronic acid hydrogel, melt electrowriting of thermoplastic polycaprolactone-polyurethane elastomer, and shape transformation. [ACS Applied Bio Materials] |
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| Deletion of mineralocorticoid receptor from smooth muscle cells attenuated transverse aortic constriction-induced heart failure with statistically significant improvements in ejection fraction, cardiac stiffness, chamber dimensions, intracardiac pressure, pulmonary edema, and exercise capacity. [Circulation-Heart Failure] |
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| Using human coronary artery smooth muscle cells researchers found that the transcriptional co-activator MRTFA promoted lipid accumulation via several mechanisms, including direct transcriptional control of LDL receptor, enhanced fluid-phase pinocytosis and reduced lipid efflux. [Vascular Pharmacology] |
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| Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions. [Signal Transduction and Targeted Therapy] |
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| The authors introduce recently developed technologies and the mechanistic insights they provide to the understanding of muscle stem cell biology, including the re-definition of quiescence and Galert states. [Nature Communications] |
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| Asklepios BioPharmaceutical, Inc. announced that the clinical team from Brain Neurotherapy Bio, Inc. has joined AskBio to expand its clinical pipeline for the treatment of neurodegenerative disorders. [Asklepios BioPharmaceutical, Inc.] |
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| May 17 – 21, 2021 Virtual |
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| University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| Mayo Clinic – Rochester, Minnesota, United States |
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| Stanford University – Stanford, California, United States |
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