| Vol. 13.04 – 2 February, 2021 |
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| Scientists demonstrated that neonatal umbilical cord (UC) is a source of extracellular vesicles (EVs) derived from MSCs. These UC-produced MSC-EVs contain abundant anti-aging signals and rejuvenate senescing adult bone marrow-derived MSCs. [Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Kruppel-like factor 11 (KLF11) recruited SIN3A/HDAC to suppress the transcriptional output of YAP/TEAD, which, in turn, promoted KLF11 transcription, forming a negative feedback loop. [Science Advances] |
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| Researchers report MSC-derived interleukin-28 (IL-28) triggered prostate cancer cell apoptosis via IL-28 receptor alpha STAT1 signaling. [Nature Communications] |
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| Scientists performed lineage tracing studies by using various genetic models and found that cardiac mesenchymal cells contribute to cardiac adipocytes in postnatal development and adult homeostasis. [Cell Reports] |
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| Investigators assessed the immunosuppressive effects of human amnion-derived MSC in a xenogeneic graft-versus host disease NOD/Shi-scid IL2rγnull mouse model using human peripheral blood mononuclear cells. [Scientific Reports] |
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| The authors describe a flow cytometric assay based on differential immunostaining of target and effector cells where bone marrow MSCs were enumerated with fluorospheres to determine the loss of target cells after co-culture with peripheral blood mononucleated cells. [Heliyon] |
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| Researchers used a chemical systems biology approach, ligand class analysis, to examine ligands designed to modulate glucocorticoid receptor activity through distinct structural mechanisms. [Nature Chemical Biology] |
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| The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing. [Nature Communications] |
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| Patients with advanced Ewing sarcoma (AES) carry a poor prognosis. Retrospectively, researchers analyzed 66 AES patients treated with allogeneic stem cell transplantation receiving HLA-mismatched versus HLA-matched grafts. [Bone Marrow Transplantation] |
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| 30.8% (28/91) of the selected genes showed altered expression and 2/3 of these genes showed positive regulation when compared to public data on gene expression in MSCs of bone marrow tissue in primary myelodysplastic syndrome. [Scientific Reports] |
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| Investigators discuss current approaches to disc regeneration, with a particular focus on cell-based therapeutic strategies, including ongoing challenges, and attempts to provide a framework to interpret current data and guide future investigational studies. [Nature Reviews Rheumatology] |
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| The authors review the literature about the differential signaling of lysophosphatidic acid through its specific receptors, which makes this lipid a versatile signaling molecule. [Signal Transduction and Targeted Therapy] |
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| MSCs demonstrate in vitro and in vivo pro-angiogenic, immuno-suppressive, and anti-fibrotic properties and appear as a promising stem cell therapy type, that may target the key pathological features of systemic sclerosis disease. [Autoimmunity Reviews] |
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| Sorrento Therapeutics, Inc. announced positive preliminary results from its Phase Ib study of human allogeneic adipose-derived MSCs (COVI-MSCâ„¢) for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome. [Sorrento Therapeutics, Inc.] |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| University of Pennsylvania Perelman School of Medicine – Philadelphia, Pennsylvania, United States |
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| Rutgers University – New Brunswick, New Jersey, United States |
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