| Vol. 13.06 – 19 February, 2021 |
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| Scientists showed that, upon stimulation of CD40, germinal center B cells upregulated the chemokine CCL22 and to a lesser extent CCL17. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that CTLA-4 blockade promoted immune cell infiltration and metabolic fitness, especially in glycolysis-low tumors. [Nature] |
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| Scientists targeted the shared IL-12Rβ1/p40 interface to design a panel of IL-12 partial agonists that preserved interferon gamma induction by CD8+ T cells but impaired cytokine production from natural killer (NK) cells in vitro. [Cell] |
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| The authors demonstrated that high, low or null expression of IRF8 in hematopoietic progenitor cells promotes differentiation toward type 1 conventional DCs, Ly6C+ monocytes or neutrophils. [Nature Immunology] |
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| Investigators used 5XFAD mice expressing human APOE4+/+ that have prominent cerebral amyloid angiopathy and parenchymal plaque pathology to assess the efficacy of HAE-4 compared to an Aβ antibody that removed parenchymal Aβ but increases amyloid-related imaging abnormalities in humans. [Science Translational Medicine] |
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| Metabolic and RNA-seq analysis of tumor-associated myeloid cells (TAMCs) revealed that the arginine-ornithine-polyamine axis was up-regulated in glioblastoma TAMCs but not in tumor-infiltrating CD8+ T cells. [Science Advances] |
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| Scientists revealed previously unidentified insights into the modulation of macrophages to regulate tumor-associated fibrosis, providing a feasible strategy to reverse the immunosuppressive environment and improve the therapeutic outcome of checkpoint immunotherapies. [Science Advances] |
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| Investigators showed induced Notch2IC-expression in follicular B (FoB) cells re-programs mature FoB cells into bona fide marginal zone B cells as was evident from the surface phenotype, localization, immunological function and transcriptome of these cells. [Nature Communications] |
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| The authors demonstrated that low-dose HDAC inhibitor trichostatin-A markedly reshaped the tumor immune microenvironment by modulating the suppressive activity of infiltrating macrophages and inhibiting the recruitment of myeloid-derived suppressor cells in various tumors. [Oncogene] |
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| Researchers focus on toll-like receptor-3 (TLR3) that was activated by double-strand RNA and promoted neuroinflammation. [Cell Death & Disease] |
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| Scientists investigated the effects on myeloid-derived suppressor cells (MDSC) differentiation and immunosuppressive function via cyclic helix B peptide (CHBP) induction. [Cell Death & Disease] |
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| Investigators demonstrated that in non-human primates, amylin deposition in heart failure contributed to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. [Communications Biology] |
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| The authors consider how distinct tissue or cellular contexts may alter the effects of inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity. [Nature Immunology] |
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| Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction. [npj Regenerative Medicine] |
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| AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands. [AIM ImmunoTech, Inc.] |
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| March 23 – 24, 2021 Virtual |
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| University of Basel – Basel, Switzerland |
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| University of Basel – Basel, Switzerland |
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| Duke University – Durham, North Carolina, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Washington – Seattle, Washington, United States |
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