| Vol. 16.07 – 24 February, 2021 |
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| The authors developed a human ESC-based model of H3.3G34R-mutant glioma that recapitulated the key features of the tumors with cell-type specificity to forebrain interneuronal progenitors but not hindbrain precursors. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report the establishment of self-renewing formative PSCs which manifest features of epiblast cells poised for gastrulation. [Cell Research] |
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| The authors showed that deficiency of retinoblastoma binding protein 4 (RBBP4), a component of the Polycomb repressive complex 2 in ESCs led to spontaneous differentiation into mesendodermal lineages. [Stem Cell Reports] |
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| Researchers applied human iPSC-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2. [Stem Cell Reports] |
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| Investigators demonstrated that CYCLIN D1 made iPSCs have lower multitelomeric signal, reduced double‐strand DNA breaks, correct nuclear localization of RAD51 protein expression, and reduced SNP changes per chromosome, compared with the classical reprogramming method using C‐MYC. [Stem Cells] |
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| Scientists defined an optimal, stepwise and completely xeno‐free culture protocol for the generation of megakaryocytes from human ESCs. [Cell Proliferation] |
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| Researchers investigated the therapeutic potential of nerve conduits coated with human iPSC-derived neurospheres in rat sciatic nerve defects. |
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| Scientists present an efficient, lentiviral transduction protocol for delivery of CRISPR/Cas9 to macrophages derived from human iPSCs with efficiencies close to 100%. [Scientific Reports] |
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| The authors investigate cell surface and genetic engineering approaches, and discuss stem cell niche engineering based on the design of matrices that allow spatiotemporal control of organoid growth and shape-guided morphogenesis. [Nature Reviews Materials] |
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| Scientists discuss the evolution of direct reprogramming from a transcription factor-based method to a small-molecule-driven approach, the recent progress in enhancing reprogrammed cell maturation, and the challenges associated with in vivo direct reprogramming for translational applications. [Nature Reviews Molecular Cell Biology] |
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| Investigators highlight how knowledge of vascular endothelial cell (EC) development in vivo is used to differentiate iPSCs into ECs. [Frontiers in Cardiovascular Medicine] |
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| Century Therapeutics announced a significant expansion of its operational and laboratory space in Philadelphia, as well as progress on its manufacturing facility in Branchburg, NJ, paving the way for a strong technical foundation as the company scales up its in-house research and development capabilities. [Century Therapeutics (Cision US Inc.)] |
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| Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| NCCR AntiResist – Basel, Switzerland |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| University of Southern California – Los Angeles, California, United States |
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