| Vol. 13.07 – 26 February, 2021 |
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| Scientists showed that inhibiting lipid synthesis and metabolic signaling that were dependent on sterol-regulatory-element-binding proteins in Treg cells unleashed effective antitumor immune responses without autoimmune toxicity. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report that impaired Early B cell Factor 1 (EBF1) function in mouse B-cell progenitors resulted in reduced expression of Myc. [Blood] |
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| The authors revealed that activation of the Hypoxia Inducible Factor-2 (HIF2α) due to deficiency of HIF-prolyl hydroxylase domain protein-2 boosted neutrophil migration specifically through highly confined microenvironments. [Blood] |
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| Scientists report that nonalcoholic steatohepatitis livers accumulate B cells with elevated pro‐inflammatory cytokine secretion and antigen‐presentation ability. [Hepatology] |
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| By surface proteome and transcriptome analysis as well as using humanized mice, researchers identified a differentiation pathway of uterine natural killer cells in vitro and in vivo with sequential acquisition of killer cell immunoglobulin-like receptors and CD39. [Science Immunology] |
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| Investigators showed single-cell RNA sequencing of CD11b+ myeloid cells in naïve and GL261 glioma-bearing mice that revealed distinct profiles of microglia, infiltrating monocytes/macrophages and central nervous system border-associated macrophages. [Nature Communications] |
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| Through modeling 5‐Fluorouracil (FU) response of murine colon and melanoma tumors, the authors report that effective reduction of tumor burden by 5‐FU was dependent on anti‐tumor immunity triggered by the activation of cancer‐cell‐intrinsic STING. [EMBO Journal] |
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| Researchers used a modified experimental autoimmune encephalomyelitis mouse model that displayed severe neuronal damage to investigate the interplay between peripheral immune cells and glial cells in the event of neuronal damage. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators found that tumor-infiltrating CD8+ T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth. [Cancer Immunology Research] |
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| Scientists demonstrated that diacylglycerol kinase alpha (Dgka) mediated T-cell dysfunction during anti-PD-1 therapy by exacerbating the exhaustion of reinvigorated tumor-specific T cells. [Cancer Immunology Research] |
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| Investigators showed that Z-DNA-binding protein 1 (ZBP1) was selectively expressed in late B cell development in both human and mouse cells and it is required for optimal T-cell-dependent humoral immune responses. [Haematologica] |
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| In epithelium-enriched areas, immune signals were also detectable and varied by subtype, with regulatory T-cell markers being higher in Basal-like vs. Luminal breast cancer. [Laboratory Investigation] |
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| In adaptive immunity, effector T cells, especially Th17 cells, lead to the pathogenesis of cardiac fibrosis, including the distal fibrosis and scar formation. Cardiomyocytes protectors, Treg cells, inhibit reduce the inflammatory response, then directly trigger the regeneration of local progenitor cell via IL-10. [Signal Transduction and Targeted Therapy] |
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| MaxiVAX SA and Minaris Regenerative Medicine GmbH have entered into a manufacturing agreement for MVX-ONCO-2, a cell-based immunotherapy for the treatment of cancers such as chordoma, head and neck, and other solid tumors. [MaxiVAX SA] |
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| University of Notre Dame – Notre Dame, Indiana, United States |
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| University of Basel – Basel, Switzerland |
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| Duke University – Durham, North Carolina, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Washington – Seattle, Washington, United States |
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