Pancreatic Cell News Volume 12.11 | Mar 23 2021

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    2021-03-23 | PACN 12.11


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.11 – 23 March, 2021
    TOP STORY

    Macropinocytosis in Cancer-Associated Fibroblasts is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness

    Investigators provided evidence that macropinocytosis was operational in the pancreatic tumor stroma. They found that glutamine deficiency triggered macropinocytic uptake in pancreatic cancer-associated fibroblasts.
    [Cancer Discovery]

    AbstractPress Release

    Watch a webinar on using patient-derived iPS cells to model diabetes.
    PUBLICATIONSRanked by the impact factor of the journal

    GIP Mediates the Incretin Effect and Glucose Tolerance by Dual Actions on α Cells and β Cells

    Scientists demonstrated that glucose-dependent insulinotropic polypeptide (GIP) potentiated amino acid–stimulated glucagon secretion, documenting a similar nutrient-dependent action to that described in β cells.
    [Science Advances]

    Full Article

    Islet Neogenesis Associated Protein (INGAP) Protects Pancreatic β Cells from IL-1β and IFNγ-Induced Apoptosis

    Researchers determined whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118, protected β cells against cytokine-induced death.
    [Cell Death Discovery]

    Full Article

    Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes

    To investigate islet sympathetic innervation in type 1 diabetes (T1D), sympathetic tyrosine hydroxylase axons were analyzed in control non-diabetic organ donors, non-diabetic islet autoantibody-positive individuals, and age-matched persons with T1D.
    [Scientific Reports]

    Full Article

    Dimethyl Sulfoxide Acutely Enhances Regulated Insulin Secretion in the MIN6-K8 Mouse Insulinoma Cell Line

    Investigators evaluated the effects of short-term exposure to dimethyl sulfoxide, a polar aprotic solvent commonly used in drug screening, on physiological characteristics of MIN6-K8 cells
    [Histochemistry and Cell Biology]

    Abstract

    Nifuroxazide Improves Insulin Secretion and Attenuates High Glucose-Induced Inflammation and Apoptosis in INS-1 Cells

    The authors used high concentration glucose-induced INS-1 cells to examine the effects of Nifuroxazide on high glucose-induced cell function by glucose-stimulated insulin secretion.
    [European Journal of Pharmacology]

    Abstract

    Pancreatic Cancer Induces Muscle Wasting by Promoting the Release of Pancreatic Adenocarcinoma Upregulated Factor

    Scientists analyzed the relation between pancreatic cancer-derived PDAC upregulated factor and cancer cachexia in mice and its clinical significance.
    [Experimental and Molecular Medicine]

    Full Article

    Preparation of Multifunctional Nanobubbles and Their Application in Bimodal Imaging and Targeted Combination Therapy of Early Pancreatic Cancer

    Researchers explored multifunctional nanobubbles named IR780-NBs-DTX as novel ultrasound contrast agents for dual-mode targeted imaging and photothermal ablation combined with chemotherapy for pancreatic cancer.
    [Scientific Reports]

    Full Article

    SWATH-MS Proteomics of PANC-1 and MIA PaCa-2 Pancreatic Cancer Cells Allows Identification of Drug Targets Alternative to MEK and PI3K Inhibition

    Scientists compared PANC-1 and MIA PaCa-2 pancreatic cancer cells which were, respectively, resistant and sensitive to MEK- and PI3K-targeted therapy.
    [Biochemical and Biophysical Research Communications]

    Abstract

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    REVIEWS

    Harnessing Metabolic Dependencies in Pancreatic Cancers

    The authors review the metabolic pathways that PDAC uses to support their growth in the setting of an austere tumor microenvironment.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Lipid Metabolism in Adaptation to Extreme Nutritional Challenges

    Scientists provide an overview of the strategies and pathways underlying the extreme capacity for animals to store and mobilize lipids during nutritionally stressful environmental conditions and highlight accompanying resilience phenotypes that allow these animals to develop and tolerate such profound metabolic phenotypes.
    [Developmental Cell]

    Full Article

    Pancreatic Cancer Cachexia: Three Dimensions of a Complex Syndrome

    Investigators conceptualize the various insights into the mechanisms underlying pancreatic cancer cachexia according to the three dimensions to expose its particular complexity and the challenges that face clinicians in trying to devise therapeutic interventions.
    [British Journal of Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    AzurRx BioPharma Announces Completion of Enrollment in Phase II Clinical Trial of MS1819 in Combination with PERT in the Treatment of Cystic Fibrosis Patients with Severe Exocrine Pancreatic Insufficiency

    AzurRx BioPharma, Inc. announced it has completed enrollment in its Phase II trial evaluating MS1819 in combination with the current standard of care, porcine-derived pancreatic enzyme replacement therapy (PERT), for the treatment of severe exocrine pancreatic insufficiency in patients with cystic fibrosis.
    [AzurRx BioPharma, Inc.]

    Press Release

    Zealand Pharma Announces FDA Approval of Zegalogue® (Dasiglucagon) injection, for the Treatment of Severe Hypoglycemia in People with Diabetes

    Zealand Pharma A/S announced that the FDA has approved dasiglucagon injection for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes aged six years and above.
    [Zealand Pharma A/S (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Endocrinology, Nutrition and Metabolism

    Rutgers University – New Brunswick, New Jersey, United States

    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Research Scientist – In Vitro Nutrition Platform

    Chr. Hansen A/S – Hørsholm, Denmark

    Postdoctoral Position – Adipocyte Biology Research

    Harvard Medical School – Boston, Massachusetts, United States,

    Postdoctoral Fellowship – Diabetes Research

    University of Michigan – Ann Arbor, Michigan, United States

    > See All Jobs

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