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| To understand why only a subset of tumors respond to immune-checkpoint blockade, patients with hormone receptor-positive or triple-negative breast cancer were treated with anti-PD1 before surgery. [Nature Medicine] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that in peanut-allergic humans, peanut allergen drove the differentiation of CD209+ monocyte-derived dendritic cells and CD23+ myeloid dendritic cells through the action of allergen-specific CD4+ T cells. [Journal of Experimental Medicine] |
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| Crystal structures showed that the short cellular sphingomyelins stabilized a triad of surface residues to remain flush with CD1a, but the longer lipids forced the phosphocholine group to ride above the display platform to hinder TCR approach. [Journal of Experimental Medicine] |
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| The authors demonstrated that DNMT3A haploinsufficiency impaired the gain of DNA methylation at decommissioned enhancers, while simultaneously and unexpectedly impairing DNA demethylation of newly activated enhancers in mature human myeloid cells. [Journal of Experimental Medicine] |
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| Researchers developed a composite costimulatory domain of a B cell signaling moiety, CD79A/CD40, to induce a nuclear translocating signal, NF-κB, to synergize with other T cell signals and improve CAR-T cell function. [Molecular Therapy] |
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| Scientists showed that tumor-associated neutrophils (TANs) actively participated in the recruitment of B cells to the tumor microenvironment and identified TNFα as the major cytokine mediating B cell chemotaxis by TANs. [Cancer Immunology Research] |
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| The authors analyzed seven million autosomal germline variants in the TCGA cohort and tested for association with established immune-related phenotypes that describe the tumor immune microenvironment. [Cell Reports] |
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| Investigators analyzed expression of immune checkpoint molecules and infiltration of immune cells in nodal samples, and peripheral blood T cell diversity in 33 chronic lymphocytic leukemia and 37 Richter syndrome patients. [Blood Cancer Journal] |
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| Researchers investigated the crosstalk between human eosinophils and esophageal epithelial cells. They reported that blood-derived eosinophils had prolonged survival when co-cultured with epithelial cells. [Mucosal Immunology] |
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| Scientists examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differed in mucosal structure and exposure to external environmental stimuli. [Mucosal Immunology] |
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| The authors summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease. [Cell Reports] |
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| In some tissues, like murine spleen, subpopulations of memory T cells proliferating in the absence of antigen (homeostatic proliferation) have been described. [Cold Spring Harbor Perspectives in Biology] |
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| NANOBIOTIX announced a partnership with LianBio to develop and commercialize Nanobiotix lead product candidate NBTXR3, a potential first-in-class radioenhancer, in Greater China, South Korea, Singapore and Thailand. [NANOBIOTIX (BusinessWire, Inc.)] |
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| A University of Kentucky College of Medicine professor has been awarded a $1.9 million National Institutes of Health grant for his research on the body’s immune response to sepsis, which could potentially help to improve therapies for the common disease. [University of Kentucky (EurekAlert!)] |
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| May 31 – June 2, 2021 Virtual |
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| Trinity College Dublin – Dublin, Republic of Ireland |
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| Université Libre de Bruxelles – Brussels, Belgium |
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| Columbia University Medical Center – New York City, New York, United States |
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| Stanford University – Palo Alto, California, United States |
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| Zhejiang University – Zhejiang, China |
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