| Vol. 15.18 – 12 May, 2021 |
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| Scientists sought potential drivers of the selective vulnerability using single-nucleus RNA sequencing and discovered that ApoE expression level was a substantial driver of neuronal variability. [Nature Neuroscience] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers determined the expression of cadherins and cell-type markers in 29,933 cells and the projections of 3,164 cells in both the mouse motor cortex and auditory cortex. [Nature Neuroscience] |
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| Scientists identified functional network parameters that were most reliably affected by GABAergic modulation as such, and through alterations of excitation/inhibition balance by reduced expression of Cadherin – 13 in GABAergic neurons. [Molecular Psychiatry] |
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| Investigators have identified 30 affected individuals from 22 unrelated families presenting with developmental delay, hypotonia, and cerebellar ataxia harboring biallelic variants in the GEMIN5 gene. [Nature Communications] |
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| Scientists generated human induced pluripotent stem cell lines from a patient with Tuberous Sclerosis Complex and genetically engineered counterparts and isogenic controls. By differentiating hiPSCs, they showed that control neurons responded to canonical guidance cues as predicted. [Nature Communications] |
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| Researchers showed that leptin receptor (LepR)-expressing neurons in arcuate (LepRArc) were selectively activated in type 1 diabetes. [Nature Communications] |
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| Scientists assessed mice and neurons treated with anesthetics sevoflurane and desflurane, and applied nanobeam-sensor technology, an ultrasensitive method, to measure tau/p-tau amounts. [Nature Communications] |
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| Investigators demonstrated that miR-3140-3p suppressed tumor cell growth in MYCN-amplified neuroblastoma by downregulating MYCN and MYC through BRD4 suppression. [Molecular Therapy-Nucleic Acids] |
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| Scientists described that human induced pluripotent stem cells-cortical neurons exposed to lithium showed an increased neuronal activity under all tested concentrations. [Translational Psychiatry] |
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| The apoptotic loss of dendritic spines would be aggravated by microglia activation through a recently described signaling system from complement abnormalities and proteins of the MHC, thus implicating the immune system in schizophrenia. [Translational Psychiatry] |
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| NOXXON Pharma, Inc. announced that an independent Data Safety Monitoring Board has confirmed that the highest dose of NOX-A12 in combination with radiotherapy in the ongoing Phase I/II study in patients with brain cancer is safe and that the trial should continue as planned. [NOXXON Pharma, Inc.] |
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| Lerner Research Institute – Cleveland, Ohio, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| Cyprus Cancer Research Institute – Republic of Cyprus |
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| University of British Columbia – Vancouver, British Columbia, Canada |
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