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| Using 3D structured illumination microscopy, scientists observed that the mitochondrial protein Mitofusin-2 co-localized at the plasma membrane with vascular endothelial-cadherin and β-catenin in endothelial cells during homeostasis. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that PACSIN2 recruited the trafficking regulators EHD4 and MICAL-L1 to the rear end of asymmetric adherens junctions to form a recycling endosome-like tubular structure. [Nature Communications] |
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| Researchers investigated the impact of cell type-specific deletion of mineralocorticoid receptor (MR) on pulmonary vascular remodeling. MR deletion from endothelial cells fully recapitulated the beneficial effects of eplerenone while MR deletion from other cell types had no detectable effect on pulmonary vascular remodeling. [Hypertension] |
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| Scientists found a decrease in endothelial cells and an increase in cells co-expressing CD31 and α-smooth muscle actin at eight weeks in heart tissue of mice subjected to transverse aortic constriction, which implied EndMT. [Cell Death & Disease] |
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| By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate. [JCI Insight] |
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| The effects of T-dental pulp stem cell (DPSC)-conditioned media on human umbilical vein endothelial cell proliferation and migration were examined by MTT, wound healing, and trans-well migration assay. [Stem Cell Research & Therapy] |
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| Angiogenesis was evaluated in the Matrigel-based human umbilical vein endothelial cell-RLC-310 coculture model and immunohistochemical staining for vascular endothelial growth factor and CD31 in tumor tissues collected from a xenograft clear cell renal cell carcinoma mouse model. [Cancer Gene Therapy] |
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| Investigators studied the role of serum‐derived small extracellular vesicles in diabetes mellitus–impaired microvascular endothelial cell function. [Journal of the American Heart Association] |
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| Researchers demonstrated that transforming growth factor-beta induced suppressed angiogenesis stimulated by adipocyte-conditioned medium, both in vitro and in vivo. [Scientific Reports] |
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| Investigators explored the angiogenesis potential of human endothelial cells encapsulated inside alginate-gelatin microspheres under static and dynamic culture systems after seven days. [Microvascular Research] |
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| Scientists consider a gamut of attractive possibilities for modifying inflammation in atherosclerosis, including targeting pivotal inflammatory pathways such as the inflammasomes, inhibiting cytokines, manipulating adaptive immunity and promoting pro-resolution mechanisms. [Nature Reviews Drug Discovery] |
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| Orgenesis, Inc. announced it has been granted Investigational Device Exemption (IDE) approval by the FDA to conduct a first-in-human feasibility study of the Tissue Genesis Icellator2® to treat Acute Respiratory Distress Syndrome (ARDS) resulting from COVID-19 infection. [Orgenesis, Inc. (GlobeNewswire, Inc.)] |
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| June 28 – 30, 2021 Virtual |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| University of Nebraska Medical Center – Omaha, Nebraska. United States |
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| Stanford University – Stanford, California, United States |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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