Endothelial Cell News Volume 6.17 | May 17 2021

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    ENDOCN 6.17 | May 17 2021


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.17 – 17 May, 2021
    TOP STORY

    Mitofusin-2 Stabilizes Adherens Junctions and Suppresses Endothelial Inflammation via Modulation of β-Catenin Signaling

    Using 3D structured illumination microscopy, scientists observed that the mitochondrial protein Mitofusin-2 co-localized at the plasma membrane with vascular endothelial-cadherin and β-catenin in endothelial cells during homeostasis.
    [Nature Communications]

    Full Article

    View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    A Junctional PACSIN2/EHD4/MICAL-L1 Complex Coordinates VE-Cadherin Trafficking for Endothelial Migration and Angiogenesis

    The authors showed that PACSIN2 recruited the trafficking regulators EHD4 and MICAL-L1 to the rear end of asymmetric adherens junctions to form a recycling endosome-like tubular structure.
    [Nature Communications]

    Full Article

    Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells

    Researchers investigated the impact of cell type-specific deletion of mineralocorticoid receptor (MR) on pulmonary vascular remodeling. MR deletion from endothelial cells fully recapitulated the beneficial effects of eplerenone while MR deletion from other cell types had no detectable effect on pulmonary vascular remodeling.
    [Hypertension]

    Abstract

    Knockout RAGE Alleviates Cardiac Fibrosis through Repressing Endothelial-to-Mesenchymal Transition (EndMT) Mediated by Autophagy

    Scientists found a decrease in endothelial cells and an increase in cells co-expressing CD31 and α-smooth muscle actin at eight weeks in heart tissue of mice subjected to transverse aortic constriction, which implied EndMT.
    [Cell Death & Disease]

    Full Article

    Loss of Diacylglycerol Kinase ε Causes Thrombotic Microangiopathy by Impairing Endothelial VEGFA Signaling

    By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate.
    [JCI Insight]

    Full ArticleGraphical Abstract

    DPSCs Treated by TGF-β1 Regulate Angiogenic Sprouting of Three-Dimensionally Co-Cultured HUVECs and DPSCs through VEGF-Ang-Tie2 Signaling

    The effects of T-dental pulp stem cell (DPSC)-conditioned media on human umbilical vein endothelial cell proliferation and migration were examined by MTT, wound healing, and trans-well migration assay.
    [Stem Cell Research & Therapy]

    Full Article

    LncRNA MAGI2-AS3 Inhibits Tumor Progression and Angiogenesis by Regulating ACY1 via Interacting with Transcription Factor HEY1 in Clear Cell Renal Cell Carcinoma

    Angiogenesis was evaluated in the Matrigel-based human umbilical vein endothelial cell-RLC-310 coculture model and immunohistochemical staining for vascular endothelial growth factor and CD31 in tumor tissues collected from a xenograft clear cell renal cell carcinoma mouse model.
    [Cancer Gene Therapy]

    Abstract

    Serum‐Derived Small Extracellular Vesicles from Diabetic Mice Impair Angiogenic Property of Microvascular Endothelial Cells: Role of EZH2

    Investigators studied the role of serum‐derived small extracellular vesicles in diabetes mellitus–impaired microvascular endothelial cell function.
    [Journal of the American Heart Association]

    Full Article

    Endothelial Angiogenic Activity and Adipose Angiogenesis Is Controlled by Extracellular Matrix Protein TGFBI

    Researchers demonstrated that transforming growth factor-beta induced suppressed angiogenesis stimulated by adipocyte-conditioned medium, both in vitro and in vivo.
    [Scientific Reports]

    Full Article

    Static and Dynamic Culture of Human Endothelial Cells Encapsulated inside Alginate-Gelatin Microspheres

    Investigators explored the angiogenesis potential of human endothelial cells encapsulated inside alginate-gelatin microspheres under static and dynamic culture systems after seven days.
    [Microvascular Research]

    Abstract

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    REVIEWS

    Targeting Inflammation in Atherosclerosis – From Experimental Insights to the Clinic

    Scientists consider a gamut of attractive possibilities for modifying inflammation in atherosclerosis, including targeting pivotal inflammatory pathways such as the inflammasomes, inhibiting cytokines, manipulating adaptive immunity and promoting pro-resolution mechanisms.
    [Nature Reviews Drug Discovery]

    Abstract

    INDUSTRY AND POLICY NEWS

    FDA Approves Orgenesis IDE for Pilot Clinical Trial of its Tissue Genesis Icellator2® to Treat ARDS Resulting from COVID-19 Infection

    Orgenesis, Inc. announced it has been granted Investigational Device Exemption (IDE) approval by the FDA to conduct a first-in-human feasibility study of the Tissue Genesis Icellator2® to treat Acute Respiratory Distress Syndrome (ARDS) resulting from COVID-19 infection.
    [Orgenesis, Inc. (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    Metabolism in Health and Disease

    June 28 – 30, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Asthma

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Research Associate – Cardiac Remodeling

    University of Nebraska Medical Center – Omaha, Nebraska. United States

    Assistant, Associate, Full Professor – Stem Cell Biology and Regenerative/Restorative Medicine

    Stanford University – Stanford, California, United States

    Postdoctoral Position – Neuronal and Endothelial Cell Relations

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Endothelial Cell Ion Channels

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    > See All Jobs

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