| Vol. 13.21 – 1 June, 2021 |
| |
|
|
| Scientists engineered bi-specific Wnt mimetics that targeted Frizzled and low-density lipoprotein receptor-related proteins and evaluated their effects on bone accrual in murine models. [Nature Communications] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Investigators presented evidence that during intramembranous bone formation osteoprogenitor cell proliferation was controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. [npj Regenerative Medicine] |
|
|
|
| The authors focused on the emerging class of RNAs called long non-coding RNAs or lncRNAs and utilized an MSC-supported triple-negative breast cancer (TNBC) progression model to identify specific family members of functional relevance to TNBC pathogenesis. [npj Breast Cancer] |
|
|
|
| Researchers determined the roles of exosomes derived from adipose mesenchymal stem cells (ADSC-Exos) in wound skin tissue repair. Flow cytometry and electron microscopy were carried out to identify ADSCs and ADSC-Exos, respectively. [Laboratory Investigation] |
|
|
|
| Investigators studied whether and to what extent the conditionally immortalized cell line hFOB 1.19 could serve as a surrogate model for bone-marrow-derived MSCs. [Scientific Reports] |
| |
|
|
| Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts. [Cell Death & Disease] |
|
|
|
| This prospective, single-arm, Phase II study evaluated the efficacy of the combination of pazopanib with topotecan in patients with metastatic or unresectable non-adipocytic soft-tissue sarcoma [British Journal of Cancer] |
|
|
|
| The safety and feasibility of using bone marrow-derived MSCs in combination with prodrug for the treatment of patients with primary and secondary glioblastoma multiform were assessed. [Molecular Neurobiology] |
|
|
|
| Researchers showed that CD13-deficient mice presented a low bone density phenotype with increased numbers of osteoclasts per bone surface, but displayed a normal distribution of osteoclast progenitor populations in the bone marrow and periphery. [Scientific Reports] |
|
|
|
|
| The authors review the evidence of autologous MSC therapy on pain, function and severity on imaging in knee osteoarthritis. [British Journal of Sports Medicine] |
|
|
|
| Investigators provide a detailed description of the functional properties of MSCs and extracellular vesicles and their potential clinical applications, with a special focus on pain treatment. [British Journal of Pharmacology] |
|
|
|
|
| Moleculin Biotech, Inc. announced it has received clearance to initiate its Phase Ib/II clinical trial evaluating Annamycin for the treatment of soft tissue sarcoma lung metastases. [Moleculin Biotech, Inc.] |
|
|
|
|
| July 12 – 15, 2021 Virtual |
|
|
|
|
|
| Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
|
|
|
| H. Lee Moffitt Cancer Center – Tampa, Florida, United States |
|
|
|
| National University of Ireland Galway – Galway, Ireland |
|
|
|
| Louisiana State University – New Orleans, Louisiana, United States |
|
|
|
| Broad Institute – Cambridge, Massachusetts, United States |
|
|
|
|