| Vol. 13.23 – 25 June, 2021 |
| |
|
|
| In lymph nodes, self-activated T cells produced interleukin-2, which enhanced local Treg proliferation and inhibitory functionality. [Cell] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Using mice that bear the corresponding variant and recapitulate the B and T cell phenotypes, researchers showed that the mutant AIOLOS homodimers and AIOLOS–IKAROS heterodimers did not bind the canonical AIOLOS–IKAROS DNA sequence. [Nature Immunology] |
|
|
|
| he authors showed in multiple murine tumor models that inulin-a widely consumed dietary fiber-formulated as a ‘colon-retentive’ orally administered gel could effectively modulate the gut microbiome in situ, induced systemic memory-T-cell responses and amplified the antitumour activity of the checkpoint inhibitor anti-programmed cell death protein-1. [Nature Biomedical Engineering] |
|
|
|
| Investigators found that the interferon gamma-regulated transcriptional program in macrophages was controlled by ADP-ribosylation of STAT1α, a post-translational modification resulting in the site-specific covalent attachment of ADP-ribose moieties. [Nature Communications] |
|
|
|
| The authors discovered that YTHDF2, a well-known N6-methyladenosine (m6A) reader, was upregulated in NK cells upon activation by cytokines, tumors, and cytomegalovirus infection. [Journal of Experimental Medicine] |
|
|
|
| By analyzing inducible gene-disrupted mice, researchers showed that DNA demethylation during primary T cell differentiation occured mainly through passive replication-dependent dilution of all three oxi-mCs, with only a negligible contribution from DNA glycosylase. [Genome Biology] |
|
|
|
| Researchers showed that Duox1 promoted antiviral innate immunity in vivo. Upon influenza airway challenge, Duox1−/− mice had enhanced mortality, morbidity, and impaired lung viral clearance. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Scientists reported that glutathione peroxidase 4 prevented Treg cells from lipid peroxidation and ferroptosis in regulating immune homeostasis and antitumor immunity. [Cell Reports] |
|
|
|
| Delivery of regulatory macrophages (Mregs) completely abolished the priming of cognate CD8 cells and strongly reduced delayed-type hypersensitivity reactions. Mreg-mediated T cell suppression requiresd cell-cell contact-regulated nitric oxide production. [Cell Reports] |
|
|
|
| Scientists showed that monocyte/macrophage CD11B mRNA levels were increased significantly in livers of biliary atresia patients and positively correlated with the progression of liver inflammation and fibrosis. [Cell Death & Disease] |
|
|
|
| Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass. [JCI Insight] |
|
|
|
| A highly acidified microenvironment of melanoma induced the expression of G-protein-coupled receptor in T cells, which weakened their effective function and promoted tumor growth. [Cancer Gene Therapy] |
|
|
|
| A porcine endothelial cell was characterized and immortalized for genetic modification. Five genes including GGTA1, CMAH, β4galNT2, SLA-I α chain, and β2-microglobulin that were responsible for the production of major xenoantigens were sequentially disrupted in immortalized porcine endothelial cells using CRISPR/Cas9 technology. [Scientific Reports] |
| |
|
|
|
| Autoimmune hepatitis is a chronic inflammatory liver disease affecting all ages, characterized by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis on histology and good response to immunosuppressive treatment. [Digestive and Liver Disease] |
|
|
|
| The authors describe recently published information describing the mechanism of action of prominent nutritional intervention agents where evidence exists as to their action and potency. [European Journal of Clinical Nutrition] |
|
|
|
|
| Corbus Pharmaceuticals Holdings, Inc. announced topline results from the Phase III DETERMINE study of lenabasum in adults with the rare, heterogeneous, autoimmune disease dermatomyositis. [Corbus Pharmaceuticals Holdings, Inc.] |
|
|
|
| Invivoscribe announced the launch of an Immune Biomarker Discovery grant program, focused on supporting development, validation and deployment of novel applications for use of their distributed LymphoTrack® NGS products and bioinformatics software. [Invivoscribe, Inc.] |
|
|
|
|
| August 6 – 7, 2021 Marysville, Victoria, Australia |
|
|
|
|
|
| Weill Cornell Medical College – New York, New York, United States |
|
|
|
| Research Center for Molecular Medicine – Vienna, Austria |
|
|
|
| Hummingbird Bioscience – Singapore, Singapore |
|
|
|
| University of Gothenburg – Gothenburg, Sweden |
|
|
|
| University of Oxford – Oxford, England, United Kingdom |
|
|
|
|