 | | Vol. 10.28 – 21 July, 2021 |
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| Investigators performed a metabolic drug screen to identify leukemic stem cell (LSC)-specific vulnerabilities and found that nicotinamide phosphoribosyltransferase inhibitors selectively killed LSCs while sparing normal hematopoietic stem and progenitor cells.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that tumor endothelial marker 8 (TEM8) was abundantly expressed in triple-negative breast cancer and served as a marker for vasculogenic mimicry-forming breast tumor-initiating cells.
[Nature Communications] |
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| Because the environmental and lifestyle factors that impact CSC populations are not clear, scientists sought to understand the consequences of diet on CSC enrichment.
[Journal of Clinical Investigation] |
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| Researchers provided an in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
[npj Precision Oncology] |
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| Scientists established oxaliplatin resistant gastric cancer organoids and evaluated their gene expression profile using microarray analysis.
[Gastric Cancer] |
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| Functional assays demonstrated that SLC38A4 depletion promoted hepatocellular carcinoma (HCC) cellular proliferation, stemness, and migration, and inhibited HCC cellular apoptosis in vitro, and further repressed HCC tumorigenesis in vivo.
[British Journal of Cancer] |
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| Investigators identified miR-324-5p as a critical epigenetic regulator of cancer stemness and demonstrated its role in mediating gain-of-function -mutant p53-driven stemness phenotype.
[Molecular Cancer Research] |
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| The authors demonstrated that FOSL1 directly regulated four transcription factors bind to their promoter regions was involved in the deregulation of several stemness markers, and reduced the cells’ ability to generate aggregates increasing the extracellular matrix component FN1.
[Scientific Reports] |
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| Researchers identified a small subset of sphere-forming cells possessed tumor stem-like cell properties in rat prolactinoma MMQ cells, which were resistant to dopamine agonist treatment.
[Molecular and Cellular Endocrinology] |
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| Scientists investigated the Regorafenib resistance mechanism of CSCs in hepatocellular carcinoma. They used sphere formation and soft agar colony formation assays to evaluate the stemness capacity of cancer cells.
[Journal of Gastroenterology and Hepatology] |
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| Researchers evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness, and invasion of these cells.
[Gene] |
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| The authors summarize the temozolomide (TMZ)-resistance mechanisms and discuss several potential therapies from conservative opinion of glioma stem cell-targeted therapy orientation to current view of TMZ resistance-aimed efficacy.
[Cancer Investigation] |
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| Oblato, Inc. announced that it has received an agreement from the FDA for its plan to submit an intermediate size expanded access protocol for use of OKN-007 in patients with high-grade gliomas.
[Oblato, Inc.] |
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| LAVA Therapeutics N.V. announced the dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-051 in patients with relapsed and/or refractory chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia.
[LAVA Therapeutics, N.V.] |
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| October 28 – 29, 2021
Virtual |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, United States |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | UC San Diego School of Medicine – San Diego, California, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
