| Vol. 9.30 – 3 August, 2021 |
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| Researchers used two unbiased chemical proteomic strategies to show that small-molecule LDC7559, or a more potent designed analog NA-11, inhibited the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type and dampening flux through the pentose phosphate pathway. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists examined the immunological features and metabolic microenvironment of untreated individuals with inflammatory bowel disease by multiomics analyses. [Immunity] |
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| Researchers focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes. [Immunity] |
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| Scientists confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus infection before and after treatment. [Nature Immunology] |
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| Using cells from patients and newly generated mouse models, investigators uncovered ELF4-mutant macrophages having hyperinflammatory responses to a range of innate stimuli. [Nature Immunology] |
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| Scientists showed that NK-cell suppression of T cells was associated with transient accumulation of NK cells within T cell-rich sites of the spleen during lymphocytic choriomeningitis virus infection. [Journal of Clinical Investigation] |
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| Using ex vivo human primary T cells, researchers found that PIP4K activity was required for Treg cell signaling and immunosuppressive activity. [Proceedings of the National Academy of Sciences of the United States of America] |
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| To establish a benchmark of human Treg dysfunction, the authors targeted the master transcription factor FOXP3 in naive and memory Tregs. Although FOXP3-ablated Tregs upregulated cytokine expression, effects on suppressive capacity in vitro manifested slowly and primarily in memory Tregs. [Cell Reports] |
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| Investigators used recently described RNA ligands for toll-like receptor (TLR)7 and TLR8 together with Vγ9Vδ2 T-cell specific pyrophosphate antigens to analyze the rapid cytokine induction in Vδ2 T cells as well as the accessory cell requirements. [Scientific Reports] |
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| Scientists determined whether the amount of corneal inflammatory cells measured by corneal confocal microscopy detects disease activity in chronic inflammatory demyelinating polyneuropathy. [Scientific Reports] |
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| The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases. [Nature Reviews Rheumatology] |
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| | | Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders. [Beyond Celiac] |
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| | | September 13 – 15, 2021 Virtual |
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| | | | University of California Irvine – Irvine, California, United States |
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| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Mercer University – Savannah, Georgia, United States |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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