| Vol. 5.31 – 13 August, 2021 |
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| Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma in individuals infected with the hepatitis virus. AHR-deficient cells tolerated high concentrations of aflatoxin B1 (AFB1), in which AFB1 adduct formation was significantly decreased. [Signal Transduction and Targeted Therapy] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists provided proof-of-concept that in vitro pharmacological inhibition of eukaryotic initiation factor 6 (eIF6) activity recapitulated the protective effects of eIF6 depletion. [Nature Communications] |
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| Researchers showed that nanodelivery of bile acid receptor modulators elicited robust antitumor immune responses and significantly changed the immune microenvironment in the murine hepatic tumor. In addition, ex vivo stimulation on both murine and patient hepatic tumor tissues suggested the observation might be meaningful for clinical practice. [Nano Letters] |
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| Scientists found that PA treatment or direct stimulation of STING1 promoted, whereas STING1 deficiency impaired, MTORC1 activation, suggesting that STING1 was involved in PA-induced MTORC1 activation. [Autophagy] |
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| Investigators showed genetic deletion and viral knockdown of hepatocyte-specific endothelial nitric oxide synthase (eNOS) exacerbated hepatic steatosis and inflammation, decreased hepatic mitochondrial fatty acid oxidation and respiration, increased mitochondrial H2O2 emission, and impaired the hepatic mitophagic response. [Diabetes] |
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| The levels of Nuclear factorÂκB65 (NF-κBp65) and NF-κBp65 phosphorylation were assessed in including normal liver, primary hepatocellular carcinoma and paired paracancerous tissues. [Journal of Experimental & Clinical Cancer Research] |
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| Researchers showed that spatial hepatocellular carcinoma tissue profiling of N-linked glycosylation by matrix-assisted laser desorption ionization imaging mass spectrometry might serve as a new method to evaluate the tumor heterogeneity. [Molecular Cancer Research] |
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| Scientists showed that cellular communication of exosomal TNF-α from Huh-7 regulatesdosteoclast differentiation through NF-κB/CTSK/TRAP expressions. [Journal of Biological Chemistry] |
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| Primary telocytes (TCs) from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in hepatocellular carcinoma, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo. [Cell Death Discovery] |
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| Scientists demonstrated that palmitate upregulated nicotinamide N-methyltransferase (NNMT) expression via activating activating transcription factor 4 (ATF4) in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent mechanism in that mTORC1 inhibition by both Torin1 and rapamycin attenuated ATF4 activation and NNMT upregulation. [American Journal of Physiology-Cell Physiology] |
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| The authors review the combined cellular immunotherapeutic approaches and the existing obstacles for primary liver cancer treatment. [Journal of Experimental & Clinical Cancer Research] |
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| Researchers from the University of Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine and Carnegie Mellon University’s Computational Biology Department have been awarded almost $1.5 million from the National Science Foundation to develop new approaches for producing liver organoids -tiny, lab-grown human organs that have potential for disease modeling, drug discovery and transplantation. [Univeristy of Pittsburgh Medicine] |
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| October 27 – 29, 2021 Virtual |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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| University Hospital of Würzburg – Würzburg, Germany |
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| University of Oslo – Oslo, Norway |
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| Helmholtz Zentrum München – Munich, Germany |
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| Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States |
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