Hepatic Cell News Volume 5.31 | Aug 13 2021

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    2021-08-13 | HCN 5.31


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.31 – 13 August, 2021
    TOP STORY

    AHR Mediates the Aflatoxin B1 Toxicity Associated with Hepatocellular Carcinoma

    Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma in individuals infected with the hepatitis virus. AHR-deficient cells tolerated high concentrations of aflatoxin B1 (AFB1), in which AFB1 adduct formation was significantly decreased.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Webinar: Organoids as Models for Human Disease
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting of eIF6-Driven Translation Induces a Metabolic Rewiring That Reduces NAFLD and the Consequent Evolution to Hepatocellular Carcinoma

    Scientists provided proof-of-concept that in vitro pharmacological inhibition of eukaryotic initiation factor 6 (eIF6) activity recapitulated the protective effects of eIF6 depletion.
    [Nature Communications]

    Full Article

    Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy

    Researchers showed that nanodelivery of bile acid receptor modulators elicited robust antitumor immune responses and significantly changed the immune microenvironment in the murine hepatic tumor. In addition, ex vivo stimulation on both murine and patient hepatic tumor tissues suggested the observation might be meaningful for clinical practice.
    [Nano Letters]

    AbstractGraphical Abstract

    Lipotoxicity-Induced STING1 Activation Stimulates MTORC1 and Restricts Hepatic Lipophagy

    Scientists found that PA treatment or direct stimulation of STING1 promoted, whereas STING1 deficiency impaired, MTORC1 activation, suggesting that STING1 was involved in PA-induced MTORC1 activation.
    [Autophagy]

    Abstract

    Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH

    Investigators showed genetic deletion and viral knockdown of hepatocyte-specific endothelial nitric oxide synthase (eNOS) exacerbated hepatic steatosis and inflammation, decreased hepatic mitochondrial fatty acid oxidation and respiration, increased mitochondrial H2O2 emission, and impaired the hepatic mitophagic response.
    [Diabetes]

    Abstract

    Phosphorylation of NF-κBp65 Drives Inflammation-Mediated Hepatocellular Carcinogenesis and Is a Novel Therapeutic Target

    The levels of Nuclear factor­κB65 (NF-κBp65) and NF-κBp65 phosphorylation were assessed in including normal liver, primary hepatocellular carcinoma and paired paracancerous tissues.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes

    Researchers showed that spatial hepatocellular carcinoma tissue profiling of N-linked glycosylation by matrix-assisted laser desorption ionization imaging mass spectrometry might serve as a new method to evaluate the tumor heterogeneity.
    [Molecular Cancer Research]

    Abstract

    Exosomal Tumor Necrosis Factor-α from Hepatocellular Cancer Cells (Huh-7) Promote Osteoclast Differentiation

    Scientists showed that cellular communication of exosomal TNF-α from Huh-7 regulatesdosteoclast differentiation through NF-κB/CTSK/TRAP expressions.
    [Journal of Biological Chemistry]

    Abstract

    Telocytes Promote Hepatocellular Carcinoma by Activating the ERK Signaling Pathway and miR-942-3p/MMP9 Axis

    Primary telocytes (TCs) from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in hepatocellular carcinoma, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo.
    [Cell Death Discovery]

    Full Article

    Nicotinamide N-Methyltransferase (NNMT) Upregulation via the mTORC1-ATF4 Pathway Activation Contributes to Palmitate-Induced Lipotoxicity in Hepatocytes

    Scientists demonstrated that palmitate upregulated nicotinamide N-methyltransferase (NNMT) expression via activating activating transcription factor 4 (ATF4) in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent mechanism in that mTORC1 inhibition by both Torin1 and rapamycin attenuated ATF4 activation and NNMT upregulation.
    [American Journal of Physiology-Cell Physiology]

    Abstract

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    REVIEWS

    Cellular Based Immunotherapy for Primary Liver Cancer

    The authors review the combined cellular immunotherapeutic approaches and the existing obstacles for primary liver cancer treatment.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    INDUSTRY AND POLICY NEWS

    UPMC-Pitt Researchers Receive Grant to Advance Liver Organoids

    Researchers from the University of Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine and Carnegie Mellon University’s Computational Biology Department have been awarded almost $1.5 million from the National Science Foundation to develop new approaches for producing liver organoids -tiny, lab-grown human organs that have potential for disease modeling, drug discovery and transplantation.
    [Univeristy of Pittsburgh Medicine]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Molecular Cell Biology

    University of Luxembourg – Luxembourg City, Luxembourg

    PhD Student – Liver Metastases

    University Hospital of Würzburg – Würzburg, Germany

    Postdoctoral fellow – Bile Duct Immunology

    University of Oslo – Oslo, Norway

    Postdoctoral Fellow – Cell Biology of Liver Metabolism

    Helmholtz Zentrum München – Munich, Germany

    Postdoctoral Fellowship – Fatty Liver Disease

    Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States

    > See All Jobs

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