| Vol. 7.29 – 16 August, 2021 |
| | | Scientists identified Troy as a marker of interfollicular epidermis and associated hair follicles infundibulum basal layer cells in developing and adult human and mouse epidermis. [Stem Cell Reports] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Skin-derived precursors (SKPs) exhibited great potential as stem cell-based therapies for hair regeneration; however, the proliferation and hair-inducing capacity of SKPs gradually decreased during culturing. [Cell Proliferation] |
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| The obtained nanoparticles have shown low toxicity in keratinocytes, however, higher loadings of cannabidiol or curcumin resulted in increased toxicity. The nanoparticles effectively internalized into keratinocytes, implying their applicability for dermal delivery. [International Journal of Pharmaceutics] |
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| Researchers investigated the process of pedicle wound healing at the organ, tissue, cell, and molecular levels. Their results convincingly demonstrated that wounds over the pedicle preceded a regenerative healing process including regeneration of skin appendages, such as hair follicles. [Cell and Tissue Research] |
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| Scientists reported that mouse skin hair follicle stem cell (HFSC) aging was initiated by their intrinsic upregulation of miR-31, a microRNA that could be induced by physical injury or genotoxic stress and was also strongly upregulated in aged human skin epithelium. [Nature Aging] |
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| Researchers performed whole exome sequencing on BRAF-V600E mutant melanoma patient tumors refractory to the combination of BRAF/MEK inhibition and identified acquired oncogenic mutations in NRAS and loss of the tumor suppressor gene CDKN2A. [Molecular Cancer Therapeutics] |
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| In vitro experiments showed that IO–PG–DOX–Ce6 markedly increased Ce6 uptake in mouse melanoma cells, leading to much-enhanced photocytotoxicity characterized by intensified reactive oxygen species production, loss of viability, DNA damage, and stimulation of tumor cell immunogenicity. [Molecular Pharmaceutics] |
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| cRGD–R9–cholesterol–PEI–PEG nanoparticles were designed for Wee1 siRNA delivery to form an RRCPP/siWee1 complex, which significantly silenced the expression of the WEE1 gene and induced B16 tumor cell apoptosis by abrogating the G2M checkpoint and DNA damage in vitro. [Molecular Pharmaceutics] |
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| To identify how circular RNA circRNA_0082835 impacted melanoma cells and lymphatic metastasis to observe whether it exerted effects through its action mechanism of sponging microRNA miR-429. [Bioengineered] |
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| Scientists highlight the potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing. [Stem Cell Research & Therapy] |
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| The authors review recent in vitro and in vivo developments in multifunctional electrospun nanofibers for wound healing. [Journal of Biomedical Materials Research Part A] |
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| Dermavant Sciences, Inc. announced that the US FDA accepted for filing the company’s New Drug Application (NDA) for tapinarof for the treatment of plaque psoriasis in adult patients. [Dermavant Sciences, Inc.] |
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| September 12 – 15, 2021 St. Louis, Missouri, United States |
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| University of California Irvine – Irvine, California, United States |
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| The Scripps Research Institute – La Jolla, California, United States |
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| Buck Institute for Research on Aging – Novato, California, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| Dalhousie University – Halifax, Nova Scotia, Canada |
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