| Vol. 13.31 – 20 August, 2021 |
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| Blood and tumors were analyzed from Intrahepatic cholangiocarcinomapatients (iCCA) and controls. Treatment and correlative studies were performed in mice with autochthonous and established orthotopic iCCA tumors treated with anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) monoclonal antibody. [Gut] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer revealed that the aggressive tumor niche was characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes. [Nature Communications] |
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| Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways. [Nature Communications] |
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| Scientists mice with endothelial-specific overexpression of DEL-1 were protected from arthritis relative to WT controls, while arthritis was exacerbated in DEL-1-deficient mice. [Journal of Clinical Investigation] |
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| The authors immunized wild-type mice with insulin as a common self-antigen and monitored diabetes symptoms as a measure for autoimmune disease. [EMBO Journal] |
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| In mouse models, investigators assessed whether dextran sodium sulfate-mediated colitis could exert lingering effects on dopaminergic pathways in the brain and whether colitis increased vulnerability to a subsequent exposure to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. [Acta Neuropathologica Communications] |
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| The antitumour activity of lenvatinib in immunocompetent and immunodeficient mice was compared to determine the role of T cell immunity. The antitumour activity of T cells was analyzed by cytokine production and adoptive T cell therapy. [Pharmacological Research] |
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| Researchers explored the relationship between lncRNAs and immune response and to construct an immune-related competing endogenous RNA network in periodontitis. [Journal of Clinical Periodontology] |
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| Scientists examined the cellular and molecular elements that promoted CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice. [Journal of Immunology] |
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| The authors summarize conventional and state-of-the-art technologies in the field of immunogenomics, single-cell and artificial intelligence, and present prospects for future research. [Signal Transduction and Targeted Therapy] |
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| Understanding the mechanisms underpinning the effects of neutrophils on lymph node immune cells and adaptive immunity could facilitate the development of neutrophil-targeted therapies in inflammatory diseases. [Immunology] |
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| Cytocom, Inc. announced a collaboration agreement to fund research and laboratory facilities at the La Jolla Institute for Immunology. The agreement is directed to research that will support the development of potential new immune-modulating agents targeting toll-like receptors for the treatment of cancer, infectious, autoimmune and chronic inflammatory diseases. [Cytocom, Inc.] |
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| Harvard Medical School in Boston and Clalit Research Institute in Tel Aviv are launching a joint precision medicine effort, enabled by a donation from the Berkowitz family, with the intent of untangling the precise factors that underlie such medical mysteries can illuminate individualized treatments based on a person’s genetic predispositions, immune profile, health history, and lifestyle. [The Harvard Gazette] |
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| February 7 – 8, 2022 San Diego, California, United States |
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| Dana-Farber Cancer Institute- Boston, Massachusetts, United States |
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| Medical College of Georgia, Augusta University – Augusta, Georgia, United States |
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| Purdue University – West Lafayette, Indiana, United States |
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| University Of Wisconsin–Madison – Madison, Wisconsin, United States |
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| National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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