| Vol. 9.33 – 24 August, 2021 |
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| Researchers identified gut bacteria that synthesized isoalloLCA from 3-oxolithocholic acid and uncovered a gene cluster responsible for the conversion in members of the abundant human gut bacterial phylum Bacteroidetes. [Cell Host & Microbe] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using RNA sequencing in 269 tumor samples from 160 lung cancer patients researchers quantified the inter-tumor heterogeneity of immune gene expression and immune cell abundance and evaluated the association of median immune cell abundance with clinical/pathological features and overall survival. [Journal of the National Cancer Institute] |
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| The authors reported a stromal cell-free, microbead-based approach that supported the efficient in vitro development of both human progenitor T cells and T-lineage cells from CD34+ cells sourced from cord blood, GCSF-mobilized peripheral blood, and PSCs. [Nature Communications] |
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| Investigators used an MHC Associated Peptide Proteomics assay to identify SaCas9 peptides presented by MHC Class II (MHC-II) proteins on dendritic cells. [Nature Communications] |
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| Scientists demonstrated that ZFP91 perturbed T cell metabolic and functional states in the tumor microenvironment and suggested that targeting ZFP91 may improve the efficacy of cancer immunotherapy. [Journal of Clinical Investigation] |
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| The authors showed that large deletions were ubiquitous but were dependent on editing sites and cell types. Human primary T cells displayed more significant deletions than hematopoietic stem and progenitor cells, whereas they observed low levels in induced pluripotent stem cells. [Genome Biology] |
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| Researchers sought to identify epigenetic and transcriptomic features of cytokine production capacity in circulating monocytes during community-acquired pneumonia. [Genome Medicine] |
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| Gene expression analysis revealed a typical developmental program in immune cells in accordance with their functional maturation, possibly involving metabolic reprogramming. [Cell Reports] |
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| Scientists used genetic engineering to create human PSCs in which the majority of the polymorphic human leukocyte antigens, the main drivers of allogeneic rejection, were deleted. [Cell Reports] |
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| The authors examined how these diverse responses are orchestrated in human dendritic cells (DCs). Single-cell analyses revealed that the response to modified vaccinia virus Ankara infection in DCs was limited to early viral gene expression. [Science Signaling] |
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| To design CARs with a lower activation threshold, scientists compared antigen-induced pathway signaling in human T cells expressing a current CAR construct to that in cells with endogenous T cell receptors (TCRs). [Science Signaling] |
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| Scientists sought to understand how the programmed death ligand 1 inhibitor durvalumab and the immunomodulatory agent pomalidomide regulated immune cell activation and function in patients with relapsed/refractory multiple myeloma. [Scientific Reports] |
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| The authors describe the immune niches within the brain, the contribution of professional immune cells to brain functions, the bidirectional relationships between the central nervous system and the immune system and the relevance of immune components to brain aging and neurodegenerative diseases. [Nature Immunology] |
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| Bristol Myers Squibb announced that the FDA has accepted its supplemental Biologics License Application for Orencia for the prevention of moderate to severe aGvHD in patients six years of age and older receiving unrelated donor hematopoietic stem cell transplantation. [Bristol Myers Squibb] |
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| October 13 – 14, 2021 Virtual |
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| National University of Ireland Galway – Galway, Ireland |
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| Epitopea – Cambridge, England, United Kingdom |
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| Washington University School of Medicine – St. Louis, Missouri, United States |
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| University of California Irvine – Irvine, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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