| Vol. 6.32 – 20 September, 2021 |
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| Researchers showed that human induced pluripotent stem cell-derived cardiomyocytes from patients with rs2229774 and who suffered doxorubicin-induced cardiotoxicity were more sensitive to doxorubicin. [Current Biology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that cytochrome c oxidase subunit 5a expression was noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulated other identified proteins, and was closely related to hypoxia-induced cell death. [Experimental and Molecular Medicine] |
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| Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours. [Acta Pharmacologica Sinica] |
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| The authors demonstrated that hypoxia up-regulated insulin-like growth factor binding protein-1 (IGFBP-1) and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α was essential to IGFBP-1 function in cellular apoptosis. [Cell Death Discovery] |
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| Investigators characterized macrophages in hearts early infused with isoproterenol as compared to control and failing hearts and evaluated the role of upregulated CX3CL1 in cardiac remodeling. [Scientific Reports] |
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| Using multiple screening assays upstream and downstream of miR-29a signaling, scientists located the secreted protein and adipogenic inhibitor SPARC to an fibroblast growth factor-2 (FGF-2) signaling pathway that was conserved between skeletal muscle cells from mice and humans and that was activated in skeletal muscle of aged mice and humans. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators studied terminally differentiated post-mitotic skeletal muscle cells in which oxidative stress induced the dynamic activation of PRC2-Ezh1 through embryonic ectoderm development shuttling to the nucleus and identified lncRNA Malat-1 as a necessary partner for PRC2-Ezh1-dependent response to oxidative stress. [Cell Death & Disease] |
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| Researchers demonstrated efficient editing of master transcription factor (TF) Myod1 locus using the CRISPR/Cas9/AAV9-sgRNA system in juvenile satellite cells (SCs). Application on two key TFs, MYC and BCL6, unveiled distinct functions in SC activation and muscle regeneration. [Stem Cell Reports] |
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| Scientists developed a non-cancer lineage with CRISPR-Cas9-mediated H19 knockdown and observed the changes in a cellular context. To edit the promoter region of H19, two RNA guides were designed, and the murine C2C12 myoblast cells were transfected. [Scientific Reports] |
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| Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension. [Molecular Therapy-Nucleic Acids] |
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| The authors investigated whether mitofusin-2 (Mfn-2) gene related peptide enhanced apoptotic activities to inhibit vascular smooth muscle cell accumulation and neointimal hyperplasia in rats with carotid balloon injury. [Journal of Translational Medicine] |
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| Scientists determined the role and mechanism of circRNA‑glutamate metabotropic receptor 1 (circ-Grm1) in pulmonary artery smooth muscle cell proliferation and migration in hypoxic pulmonary hypertension. [International Journal of Molecular Medicine] |
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| The authors appraise the complex contribution of the non-sarcomeric, hypertrophic cardiomyopathy-associated genes to cardiomyopathies across a range of variant classes, which provides insights into the genetic basis of cardiomyopathies, causal genes at genome-wide association studies loci and the application of clinical genetic testing. [Nature Reviews Cardiology] |
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| Scientists focus on the regulatory network guiding the progression of muscle stem cells to differentiated progeny. They summarize recent findings regarding the mechanisms directing myogenic cell fate decision and differentiation, with a particular focus on three-dimensional chromosome architecture and long noncoding RNA-associated chromatin accessibility changes. [Current Opinion in Cell Biology] |
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| BridgeBio Pharma, Inc. announced that the US FDA granted Fast Track designation for the investigation of BBP-418 as a treatment option for LGMD2i. [BridgeBio Pharma, Inc.] |
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| October 14, 2021 Wädenswil, Switzerland |
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| University of Iowa – Iowa City, Iowa, United States |
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| Queen’s University Belfast – Belfast, Ireland |
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| Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States |
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| European Centre Study Diabetes – Strasbourg, France |
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| Stanford University – La Jolla, California, United States |
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